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Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion

BACKGROUND: Celecoxib, a selective cyclo-oxygenase-2 inhibitor has been recommended orally for the treatment of arthritis and osteoarthritis. Long term oral administration of celecoxib produces serious gastrointestinal side effects. It is a highly lipophilic, poorly soluble drug with oral bioavailab...

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Detalles Bibliográficos
Autores principales:	Shakeel, Faiyaz, Baboota, Sanjula, Ahuja, Alka, Ali, Javed, Shafiq, Sheikh
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481266/ https://www.ncbi.nlm.nih.gov/pubmed/18613981 http://dx.doi.org/10.1186/1477-3155-6-8

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