Impaired Spatial Learning Strategies and Novel Object Recognition in Mice Haploinsufficient for the Dual Specificity Tyrosine-Regulated Kinase-1A (Dyrk1A)

BACKGROUND: Pathogenic aneuploidies involve the concept of dosage-sensitive genes leading to over- and underexpression phenotypes. Monosomy 21 in human leads to mental retardation and skeletal, immune and respiratory function disturbances. Most of the human condition corresponds to partial monosomie...

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Detalles Bibliográficos
Autores principales: Arqué, Glòria, Fotaki, Vassiliki, Fernández, David, de Lagrán, María Martínez, Arbonés, Maria L., Dierssen, Mara
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481280/
https://www.ncbi.nlm.nih.gov/pubmed/18648535
http://dx.doi.org/10.1371/journal.pone.0002575

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