Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS

BACKGROUND: Accumulating evidence indicates that RNA oxidation is involved in a wide variety of neurological diseases and may be associated with neuronal deterioration during the process of neurodegeneration. However, previous studies were done in postmortem tissues or cultured neurons. Here, we use...

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Detalles Bibliográficos
Autores principales: Chang, Yueming, Kong, Qiongman, Shan, Xiu, Tian, Guilian, Ilieva, Hristelina, Cleveland, Don W., Rothstein, Jeffrey D., Borchelt, David R., Wong, Philip C., Lin, Chien-liang Glenn
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481395/
https://www.ncbi.nlm.nih.gov/pubmed/18682740
http://dx.doi.org/10.1371/journal.pone.0002849

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