Assignment of isochores for all completely sequenced vertebrate genomes using a consensus

We show that although the currently available isochore mapping methods agree on the isochore classification of about two-thirds of the human DNA, they produce significantly different results with regard to the location of isochore boundaries and isochore length distribution. We present a new consens...

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Detalles Bibliográficos
Autores principales: Schmidt, Thorsten, Frishman, Dmitrij
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481423/
https://www.ncbi.nlm.nih.gov/pubmed/18590563
http://dx.doi.org/10.1186/gb-2008-9-6-r104
Descripción
Sumario:We show that although the currently available isochore mapping methods agree on the isochore classification of about two-thirds of the human DNA, they produce significantly different results with regard to the location of isochore boundaries and isochore length distribution. We present a new consensus isochore assignment method based on majority voting and provide IsoBase, a comprehensive on-line database of isochore maps for all completely sequenced vertebrate genomes.

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