A mouse plasma peptide atlas as a resource for disease proteomics

We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 prot...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Qing, Menon, Rajasree, Deutsch, Eric W, Pitteri, Sharon J, Faca, Vitor M, Wang, Hong, Newcomb, Lisa F, DePinho, Ronald A, Bardeesy, Nabeel, Dinulescu, Daniela, Hung, Kenneth E, Kucherlapati, Raju, Jacks, Tyler, Politi, Katerina, Aebersold, Ruedi, Omenn, Gilbert S, States, David J, Hanash, Samir M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481425/
https://www.ncbi.nlm.nih.gov/pubmed/18522751
http://dx.doi.org/10.1186/gb-2008-9-6-r93
Descripción
Sumario:We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis.

Ejemplares similares