Cargando…

Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53(+/- )mice

INTRODUCTION: Treatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53. The following experiments tested whether exogenous E+P primes p53 to be more responsive to DNA damage and whether these pathways conf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dunphy, Karen A, Blackburn, Anneke C, Yan, Haoheng, O'Connell, Lauren R, Jerry, D Joseph
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481490/ https://www.ncbi.nlm.nih.gov/pubmed/18471300 http://dx.doi.org/10.1186/bcr2094

Ejemplares similares

Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer?
por: Blackburn, Anneke C, et al.
Publicado: (2002)

siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/− with susceptibility versus C57BL/6-Trp53+/− mice with resistance to mammary tumors
por: Böhringer, M, et al.
Publicado: (2013)

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice
por: Krais, Annette M., et al.
Publicado: (2015)

Different properties of mammary carcinogenesis induced by two chemical carcinogens, DMBA and PhIP, in heterozygous BALB/c Trp53 knockout mice
por: Machida, Yukino, et al.
Publicado: (2021)

Regulation of cancer stem cells by p53
por: Jerry, D Joseph, et al.
Publicado: (2008)

Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity
por: van der Weyden, L, et al.
Publicado: (2013)

Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in the Li-Fraumeni Syndrome model, Trp53(+/-) mice
por: Blackburn, Anneke C, et al.
Publicado: (2014)

Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in Trp53+/- mice
por: Blackburn, AC, et al.
Publicado: (2012)

Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?
por: McAllister, Kimberly A, et al.
Publicado: (2002)

RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis
por: Gomes, Anielle L., et al.
Publicado: (2020)

Increased susceptibility to mammary carcinogenesis and an opposite trend in endometrium in Trp53 heterozygous knockout female mice by backcrossing the BALB/c strain onto the background C3H strain
por: Machida, Yukino, et al.
Publicado: (2019)

Hormonal control of p53 and chemoprevention
por: Jerry, D Joseph, et al.
Publicado: (2002)

Pubertal and adult windows of susceptibility to a high animal fat diet in Trp53-null mammary tumorigenesis
por: Zhu, Yirong, et al.
Publicado: (2016)

Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development
por: Huo, Yanying, et al.
Publicado: (2021)

The Trp53-Trp53inp1-Tnfrsf10b Pathway Regulates the Radiation Response of Mouse Spermatogonial Stem Cells
por: Ishii, Kei, et al.
Publicado: (2014)

p53 Regulation by TRP2 Is Not Pervasive in Melanoma
por: Houben, Roland, et al.
Publicado: (2014)

Role of JNK in a Trp53-Dependent Mouse Model of Breast Cancer
por: Cellurale, Cristina, et al.
Publicado: (2010)

In vivo genome‐editing screen identifies tumor suppressor genes that cooperate with Trp53 loss during mammary tumorigenesis
por: Heitink, Luuk, et al.
Publicado: (2022)

Maintenance of pluripotency in mouse ES cells without Trp53
por: Shigeta, Masaki, et al.
Publicado: (2013)

Differential Effects of Trp53 Alterations in Murine Colorectal Cancer
por: Betzler, Alexander M., et al.
Publicado: (2021)

Distinct oncogenic phenotypes in hematopoietic specific deletions of Trp53
por: Palanichamy, Jayanth Kumar, et al.
Publicado: (2023)

Loss of TRP53 (p53) accelerates tumorigenesis and changes the tumor spectrum of SJL/J mice
por: Branca, Jane A, et al.
Publicado: (2020)

Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation
por: Meyer, Alison E., et al.
Publicado: (2020)

Estrogen receptor alpha-positive and negative mouse mammary tumors through somatic mutations of p53 in mammary carcinogenesis
por: Lin, S-CJ, et al.
Publicado: (2003)

Chemosensitivity to doxorubicin in primary cells derived from tumor of FVB/N-Trp53(tm1Hw1) with TALEN-mediated Trp53 mutant gene
por: Yun, Woobin, et al.
Publicado: (2023)

Depletion of Trp53 and Cdkn2a Does Not Promote Self-Renewal in the Mammary Gland but Amplifies Proliferation Induced by TNF-α
por: van Weele, Linda J., et al.
Publicado: (2021)

Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes
por: Haley, Victoria L, et al.
Publicado: (2012)

Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice
por: Yue, Yangbo, et al.
Publicado: (2016)

The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice
por: Baldauf, Christina, et al.
Publicado: (2015)

Pluripotent cell derivation from male germline cells by suppression of Dmrt1 and Trp53
por: TANAKA, Takashi, et al.
Publicado: (2015)

Roles for estrogen and progesterone in breast cancer prevention
por: Jerry, D Joseph
Publicado: (2007)

Variable expressivity of the tumour suppressor protein TRP53 in cryopreserved human blastocysts
por: Chandrakanthan, Vashe, et al.
Publicado: (2007)

Brca2 and Trp53 Deficiency Cooperate in the Progression of Mouse Prostate Tumourigenesis
por: Francis, Jeffrey C., et al.
Publicado: (2010)

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice
por: Albers, Joachim, et al.
Publicado: (2013)

Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice
por: Ghosh, Shrestha, et al.
Publicado: (2018)

Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases
por: Zhang, Yun, et al.
Publicado: (2018)

p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin
Publicado: (1995)

Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway
por: Kundu, Nandini, et al.
Publicado: (2017)

Amphiregulin Mediates Estrogen, Progesterone, and EGFR Signaling in the Normal Rat Mammary Gland and in Hormone-Dependent Rat Mammary Cancers
por: Kariagina, Anastasia, et al.
Publicado: (2010)

Effect of Trp53 gene deficiency on brain injury after neonatal hypoxia-ischemia
por: Baburamani, Ana A, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_o17s5qps7uljlkdblqq6m642tv