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TIMP-2 mediates the anti-invasive effects of the nitric oxide-releasing prodrug JS-K in breast cancer cells

INTRODUCTION: Tumor invasion and metastasis remain a major cause of mortality in breast cancer patients. High concentrations of nitric oxide (NO) suppress tumor invasion and metastasis in vivo. NO prodrugs generate large amounts of NO upon metabolism by appropriate intracellular enzymes, and therefo...

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Detalles Bibliográficos
Autores principales:	Simeone, Ann-Marie, McMurtry, Vanity, Nieves-Alicea, René, Saavedra, Joseph E, Keefer, Larry K, Johnson, Marcella M, Tari, Ana M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481491/ https://www.ncbi.nlm.nih.gov/pubmed/18474097 http://dx.doi.org/10.1186/bcr2095

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