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The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?

Rheumatoid arthritis is a heterogeneous disease with respect to clinical manifestations, serologic abnormalities, joint damage and functional impairment. Predicting outcome in a reliable way to allow for strategic therapeutic decision-making as well as for prediction of the response to the various t...

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Detalles Bibliográficos
Autores principales: Smolen, Josef S, Aletaha, Daniel, Grisar, Johannes, Redlich, Kurt, Steiner, Günter, Wagner, Oswald
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483438/
https://www.ncbi.nlm.nih.gov/pubmed/18557991
http://dx.doi.org/10.1186/ar2418
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author Smolen, Josef S
Aletaha, Daniel
Grisar, Johannes
Redlich, Kurt
Steiner, Günter
Wagner, Oswald
author_facet Smolen, Josef S
Aletaha, Daniel
Grisar, Johannes
Redlich, Kurt
Steiner, Günter
Wagner, Oswald
author_sort Smolen, Josef S
collection PubMed
description Rheumatoid arthritis is a heterogeneous disease with respect to clinical manifestations, serologic abnormalities, joint damage and functional impairment. Predicting outcome in a reliable way to allow for strategic therapeutic decision-making as well as for prediction of the response to the various therapeutic modalities available today, especially biological agents, would provide means for optimization of care. In the present article, the current information on biological and clinical markers related to disease activity and joint damage as well as for predictive purposes is reviewed. It will be shown that the relationship of many biomarkers with disease characteristics is confounded by factors unrelated to the disease, and that only few biomarkers exist with some predictive value. Moreover, clinical markers appear of equal value as biomarkers for this purpose, although they likewise have limited capacity in these regards. The analysis suggests the search for better markers to predict outcomes and therapeutic responsiveness in rheumatoid arthritis needs to be intensified.
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spelling pubmed-24834382008-07-25 The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now? Smolen, Josef S Aletaha, Daniel Grisar, Johannes Redlich, Kurt Steiner, Günter Wagner, Oswald Arthritis Res Ther Review Rheumatoid arthritis is a heterogeneous disease with respect to clinical manifestations, serologic abnormalities, joint damage and functional impairment. Predicting outcome in a reliable way to allow for strategic therapeutic decision-making as well as for prediction of the response to the various therapeutic modalities available today, especially biological agents, would provide means for optimization of care. In the present article, the current information on biological and clinical markers related to disease activity and joint damage as well as for predictive purposes is reviewed. It will be shown that the relationship of many biomarkers with disease characteristics is confounded by factors unrelated to the disease, and that only few biomarkers exist with some predictive value. Moreover, clinical markers appear of equal value as biomarkers for this purpose, although they likewise have limited capacity in these regards. The analysis suggests the search for better markers to predict outcomes and therapeutic responsiveness in rheumatoid arthritis needs to be intensified. BioMed Central 2008 2008-05-29 /pmc/articles/PMC2483438/ /pubmed/18557991 http://dx.doi.org/10.1186/ar2418 Text en Copyright © 2008 BioMed Central Ltd
spellingShingle Review
Smolen, Josef S
Aletaha, Daniel
Grisar, Johannes
Redlich, Kurt
Steiner, Günter
Wagner, Oswald
The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?
title The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?
title_full The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?
title_fullStr The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?
title_full_unstemmed The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?
title_short The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?
title_sort need for prognosticators in rheumatoid arthritis. biological and clinical markers: where are we now?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483438/
https://www.ncbi.nlm.nih.gov/pubmed/18557991
http://dx.doi.org/10.1186/ar2418
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