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The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?
Rheumatoid arthritis is a heterogeneous disease with respect to clinical manifestations, serologic abnormalities, joint damage and functional impairment. Predicting outcome in a reliable way to allow for strategic therapeutic decision-making as well as for prediction of the response to the various t...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483438/ https://www.ncbi.nlm.nih.gov/pubmed/18557991 http://dx.doi.org/10.1186/ar2418 |
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author | Smolen, Josef S Aletaha, Daniel Grisar, Johannes Redlich, Kurt Steiner, Günter Wagner, Oswald |
author_facet | Smolen, Josef S Aletaha, Daniel Grisar, Johannes Redlich, Kurt Steiner, Günter Wagner, Oswald |
author_sort | Smolen, Josef S |
collection | PubMed |
description | Rheumatoid arthritis is a heterogeneous disease with respect to clinical manifestations, serologic abnormalities, joint damage and functional impairment. Predicting outcome in a reliable way to allow for strategic therapeutic decision-making as well as for prediction of the response to the various therapeutic modalities available today, especially biological agents, would provide means for optimization of care. In the present article, the current information on biological and clinical markers related to disease activity and joint damage as well as for predictive purposes is reviewed. It will be shown that the relationship of many biomarkers with disease characteristics is confounded by factors unrelated to the disease, and that only few biomarkers exist with some predictive value. Moreover, clinical markers appear of equal value as biomarkers for this purpose, although they likewise have limited capacity in these regards. The analysis suggests the search for better markers to predict outcomes and therapeutic responsiveness in rheumatoid arthritis needs to be intensified. |
format | Text |
id | pubmed-2483438 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-24834382008-07-25 The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now? Smolen, Josef S Aletaha, Daniel Grisar, Johannes Redlich, Kurt Steiner, Günter Wagner, Oswald Arthritis Res Ther Review Rheumatoid arthritis is a heterogeneous disease with respect to clinical manifestations, serologic abnormalities, joint damage and functional impairment. Predicting outcome in a reliable way to allow for strategic therapeutic decision-making as well as for prediction of the response to the various therapeutic modalities available today, especially biological agents, would provide means for optimization of care. In the present article, the current information on biological and clinical markers related to disease activity and joint damage as well as for predictive purposes is reviewed. It will be shown that the relationship of many biomarkers with disease characteristics is confounded by factors unrelated to the disease, and that only few biomarkers exist with some predictive value. Moreover, clinical markers appear of equal value as biomarkers for this purpose, although they likewise have limited capacity in these regards. The analysis suggests the search for better markers to predict outcomes and therapeutic responsiveness in rheumatoid arthritis needs to be intensified. BioMed Central 2008 2008-05-29 /pmc/articles/PMC2483438/ /pubmed/18557991 http://dx.doi.org/10.1186/ar2418 Text en Copyright © 2008 BioMed Central Ltd |
spellingShingle | Review Smolen, Josef S Aletaha, Daniel Grisar, Johannes Redlich, Kurt Steiner, Günter Wagner, Oswald The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now? |
title | The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now? |
title_full | The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now? |
title_fullStr | The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now? |
title_full_unstemmed | The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now? |
title_short | The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now? |
title_sort | need for prognosticators in rheumatoid arthritis. biological and clinical markers: where are we now? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483438/ https://www.ncbi.nlm.nih.gov/pubmed/18557991 http://dx.doi.org/10.1186/ar2418 |
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