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Paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis
Anti-tumour necrosis factor (TNF)α therapy is highly effective in rheumatoid arthritis and it is surprising, therefore, that a recent study showed that intraperitoneal administration of recombinant TNFα reduced the severity of adjuvant-induced arthritis and decreased IFNγ expression in cultured drai...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483450/ https://www.ncbi.nlm.nih.gov/pubmed/18564403 http://dx.doi.org/10.1186/ar2430 |
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author | Williams, Richard O |
author_facet | Williams, Richard O |
author_sort | Williams, Richard O |
collection | PubMed |
description | Anti-tumour necrosis factor (TNF)α therapy is highly effective in rheumatoid arthritis and it is surprising, therefore, that a recent study showed that intraperitoneal administration of recombinant TNFα reduced the severity of adjuvant-induced arthritis and decreased IFNγ expression in cultured draining lymph node cells. Furthermore, in untreated arthritic rats, maximal TNFα expression in draining lymph node cells coincided with spontaneous disease remission, suggesting a role for endogenous TNFα in recovery from arthritis. If confirmed in further studies, these findings suggest that, in addition to its well-established pro-inflammatory properties, TNFα may also play a disease-limiting role in this model of rheumatoid arthritis by suppressing effector T cell responses. |
format | Text |
id | pubmed-2483450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-24834502008-07-25 Paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis Williams, Richard O Arthritis Res Ther Editorial Anti-tumour necrosis factor (TNF)α therapy is highly effective in rheumatoid arthritis and it is surprising, therefore, that a recent study showed that intraperitoneal administration of recombinant TNFα reduced the severity of adjuvant-induced arthritis and decreased IFNγ expression in cultured draining lymph node cells. Furthermore, in untreated arthritic rats, maximal TNFα expression in draining lymph node cells coincided with spontaneous disease remission, suggesting a role for endogenous TNFα in recovery from arthritis. If confirmed in further studies, these findings suggest that, in addition to its well-established pro-inflammatory properties, TNFα may also play a disease-limiting role in this model of rheumatoid arthritis by suppressing effector T cell responses. BioMed Central 2008 2008-06-06 /pmc/articles/PMC2483450/ /pubmed/18564403 http://dx.doi.org/10.1186/ar2430 Text en Copyright © 2008 BioMed Central Ltd |
spellingShingle | Editorial Williams, Richard O Paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis |
title | Paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis |
title_full | Paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis |
title_fullStr | Paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis |
title_full_unstemmed | Paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis |
title_short | Paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis |
title_sort | paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483450/ https://www.ncbi.nlm.nih.gov/pubmed/18564403 http://dx.doi.org/10.1186/ar2430 |
work_keys_str_mv | AT williamsrichardo paradoxicaleffectsoftumournecrosisfactorainadjuvantinducedarthritis |