The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis

INTRODUCTION: IL-1β is a proinflammatory cytokine driving joint inflammation as well as systemic signs of inflammation, such as fever and acute phase protein production. METHODS: ACZ885, a fully human monoclonal antibody that neutralizes the bioactivity of human IL-1β, was generated to study the pot...

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Detalles Bibliográficos
Autores principales: Alten, Rieke, Gram, Hermann, Joosten, Leo A, Berg, Wim B van den, Sieper, Joachim, Wassenberg, Siegfrid, Burmester, Gerd, van Riel, Piet, Diaz-Lorente, Maria, Bruin, Gerardus JM, Woodworth, Thasia G, Rordorf, Christiane, Batard, Yannik, Wright, Andrew M, Jung, Thomas
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483458/
https://www.ncbi.nlm.nih.gov/pubmed/18534016
http://dx.doi.org/10.1186/ar2438

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