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High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

High-mobility group box protein 1 (HMGB1) is a non-histone nuclear protein that has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and determining chromosomal architecture. Outside the cell, HMGB1 can serve as an alarmin to activate the innate system and mediate a wide r...

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Detalles Bibliográficos
Autores principales:	Pisetsky, David S, Erlandsson-Harris, Helena, Andersson, Ulf
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483460/ https://www.ncbi.nlm.nih.gov/pubmed/18598385 http://dx.doi.org/10.1186/ar2440

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