pH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study

The crystal structure of Escherichia coli ketopantoate reductase in complex with 2′-monophosphoadenosine 5′-diphosphoribose, a fragment of NADP(+) that lacks the nicotinamide ring, is reported. The ligand is bound at the enzyme active site in the opposite orientation to that observed for NADP(+), wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ciulli, Alessio, Lobley, Carina M. C., Tuck, Kellie L., Smith, Alison G., Blundell, Tom L., Abell, Chris
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2007
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483484/
https://www.ncbi.nlm.nih.gov/pubmed/17242510
http://dx.doi.org/10.1107/S0907444906044465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483484/
https://www.ncbi.nlm.nih.gov/pubmed/17242510
http://dx.doi.org/10.1107/S0907444906044465

Ejemplares similares