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Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia

Chronic myelogenous leukaemia (CML) results from the Bcr-Abl oncoprotein, which has a constitutively activated Abl tyrosine kinase domain. Although most chronic phase CML patients treated with imatinib as first-line therapy maintain excellent durable responses, patients who have progressed to advanc...

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Detalles Bibliográficos
Autores principales:	Cowan-Jacob, Sandra W., Fendrich, Gabriele, Floersheimer, Andreas, Furet, Pascal, Liebetanz, Janis, Rummel, Gabriele, Rheinberger, Paul, Centeleghe, Mario, Fabbro, Doriano, Manley, Paul W.
Formato:	Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2006
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483489/ https://www.ncbi.nlm.nih.gov/pubmed/17164530 http://dx.doi.org/10.1107/S0907444906047287

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