HER2 Oncogenic Function Escapes EGFR Tyrosine Kinase Inhibitors via Activation of Alternative HER Receptors in Breast Cancer Cells

BACKGROUND: The response rate to EGFR tyrosine kinase inhibitors (TKIs) may be poor and unpredictable in cancer patients with EGFR expression itself being an inadequate response indicator. There is limited understanding of the mechanisms underlying this resistance. Furthermore, although TKIs suppres...

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Detalles Bibliográficos
Autores principales: Kong, Anthony, Calleja, Véronique, Leboucher, Pierre, Harris, Adrian, Parker, Peter J., Larijani, Banafshé
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483931/
https://www.ncbi.nlm.nih.gov/pubmed/18682844
http://dx.doi.org/10.1371/journal.pone.0002881

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