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Childhood TB epidemiology and treatment outcomes in Thailand: a TB active surveillance network, 2004 to 2006
BACKGROUND: Of the 9.2 million new TB cases occurring each year, about 10% are in children. Because childhood TB is usually non-infectious and non-fatal, national programs do not prioritize childhood TB diagnosis and treatment. We reviewed data from a demonstration project to learn more about the ep...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483984/ https://www.ncbi.nlm.nih.gov/pubmed/18637205 http://dx.doi.org/10.1186/1471-2334-8-94 |
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author | Lolekha, Rangsima Anuwatnonthakate, Amornrat Nateniyom, Sriprapa Sumnapun, Surin Yamada, Norio Wattanaamornkiat, Wanpen Sattayawuthipong, Wanchai Charusuntonsri, Pricha Sanguanwongse, Natpatou Wells, Charles D Varma, Jay K |
author_facet | Lolekha, Rangsima Anuwatnonthakate, Amornrat Nateniyom, Sriprapa Sumnapun, Surin Yamada, Norio Wattanaamornkiat, Wanpen Sattayawuthipong, Wanchai Charusuntonsri, Pricha Sanguanwongse, Natpatou Wells, Charles D Varma, Jay K |
author_sort | Lolekha, Rangsima |
collection | PubMed |
description | BACKGROUND: Of the 9.2 million new TB cases occurring each year, about 10% are in children. Because childhood TB is usually non-infectious and non-fatal, national programs do not prioritize childhood TB diagnosis and treatment. We reviewed data from a demonstration project to learn more about the epidemiology of childhood TB in Thailand. METHODS: In four Thai provinces and one national hospital, we contacted healthcare facilities monthly to record data about persons diagnosed with TB, assist with patient care, provide HIV counseling and testing, and obtain sputum for culture and susceptibility testing. We analyzed clinical and treatment outcome data for patients age < 15 years old registered in 2005 and 2006. RESULTS: Only 279 (2%) of 14,487 total cases occurred in children. The median age of children was 8 years (range: 4 months, 14 years). Of 197 children with pulmonary TB, 63 (32%) were bacteriologically-confirmed: 56 (28%) were smear-positive and 7 (4%) were smear-negative, but culture-positive. One was diagnosed with multi-drug resistant TB. HIV infection was documented in 75 (27%). Thirteen (17%) of 75 HIV-infected children died during TB treatment compared with 4 (2%) of 204 not known to be HIV-infected (p < 0.01). CONCLUSION: Childhood TB is infrequently diagnosed in Thailand. Understanding whether this is due to absence of disease or diagnostic effort requires further research. HIV contributes substantially to the childhood TB burden in Thailand and is associated with high mortality. |
format | Text |
id | pubmed-2483984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-24839842008-07-26 Childhood TB epidemiology and treatment outcomes in Thailand: a TB active surveillance network, 2004 to 2006 Lolekha, Rangsima Anuwatnonthakate, Amornrat Nateniyom, Sriprapa Sumnapun, Surin Yamada, Norio Wattanaamornkiat, Wanpen Sattayawuthipong, Wanchai Charusuntonsri, Pricha Sanguanwongse, Natpatou Wells, Charles D Varma, Jay K BMC Infect Dis Research Article BACKGROUND: Of the 9.2 million new TB cases occurring each year, about 10% are in children. Because childhood TB is usually non-infectious and non-fatal, national programs do not prioritize childhood TB diagnosis and treatment. We reviewed data from a demonstration project to learn more about the epidemiology of childhood TB in Thailand. METHODS: In four Thai provinces and one national hospital, we contacted healthcare facilities monthly to record data about persons diagnosed with TB, assist with patient care, provide HIV counseling and testing, and obtain sputum for culture and susceptibility testing. We analyzed clinical and treatment outcome data for patients age < 15 years old registered in 2005 and 2006. RESULTS: Only 279 (2%) of 14,487 total cases occurred in children. The median age of children was 8 years (range: 4 months, 14 years). Of 197 children with pulmonary TB, 63 (32%) were bacteriologically-confirmed: 56 (28%) were smear-positive and 7 (4%) were smear-negative, but culture-positive. One was diagnosed with multi-drug resistant TB. HIV infection was documented in 75 (27%). Thirteen (17%) of 75 HIV-infected children died during TB treatment compared with 4 (2%) of 204 not known to be HIV-infected (p < 0.01). CONCLUSION: Childhood TB is infrequently diagnosed in Thailand. Understanding whether this is due to absence of disease or diagnostic effort requires further research. HIV contributes substantially to the childhood TB burden in Thailand and is associated with high mortality. BioMed Central 2008-07-18 /pmc/articles/PMC2483984/ /pubmed/18637205 http://dx.doi.org/10.1186/1471-2334-8-94 Text en Copyright © 2008 Lolekha et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lolekha, Rangsima Anuwatnonthakate, Amornrat Nateniyom, Sriprapa Sumnapun, Surin Yamada, Norio Wattanaamornkiat, Wanpen Sattayawuthipong, Wanchai Charusuntonsri, Pricha Sanguanwongse, Natpatou Wells, Charles D Varma, Jay K Childhood TB epidemiology and treatment outcomes in Thailand: a TB active surveillance network, 2004 to 2006 |
title | Childhood TB epidemiology and treatment outcomes in Thailand: a TB active surveillance network, 2004 to 2006 |
title_full | Childhood TB epidemiology and treatment outcomes in Thailand: a TB active surveillance network, 2004 to 2006 |
title_fullStr | Childhood TB epidemiology and treatment outcomes in Thailand: a TB active surveillance network, 2004 to 2006 |
title_full_unstemmed | Childhood TB epidemiology and treatment outcomes in Thailand: a TB active surveillance network, 2004 to 2006 |
title_short | Childhood TB epidemiology and treatment outcomes in Thailand: a TB active surveillance network, 2004 to 2006 |
title_sort | childhood tb epidemiology and treatment outcomes in thailand: a tb active surveillance network, 2004 to 2006 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483984/ https://www.ncbi.nlm.nih.gov/pubmed/18637205 http://dx.doi.org/10.1186/1471-2334-8-94 |
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