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The second chance story of HIV-1 DNA: Unintegrated? Not a problem!
Accumulation of high levels of unintegrated viral DNA is a common feature of retroviral infection. It was recently discovered that coinfection of cells with integrated and unintegrated HIV-1 can result in complementation, allowing viral replication in the absence of integration. This new mode of HIV...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483994/ https://www.ncbi.nlm.nih.gov/pubmed/18613958 http://dx.doi.org/10.1186/1742-4690-5-61 |
| _version_ | 1782158084172414976 |
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| author | Wu, Yuntao |
| author_facet | Wu, Yuntao |
| author_sort | Wu, Yuntao |
| collection | PubMed |
| description | Accumulation of high levels of unintegrated viral DNA is a common feature of retroviral infection. It was recently discovered that coinfection of cells with integrated and unintegrated HIV-1 can result in complementation, allowing viral replication in the absence of integration. This new mode of HIV-1 replication has numerous implications for the function of unintegrated viral DNA and its application as a therapeutic vector. |
| format | Text |
| id | pubmed-2483994 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2008 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-24839942008-07-26 The second chance story of HIV-1 DNA: Unintegrated? Not a problem! Wu, Yuntao Retrovirology Commentary Accumulation of high levels of unintegrated viral DNA is a common feature of retroviral infection. It was recently discovered that coinfection of cells with integrated and unintegrated HIV-1 can result in complementation, allowing viral replication in the absence of integration. This new mode of HIV-1 replication has numerous implications for the function of unintegrated viral DNA and its application as a therapeutic vector. BioMed Central 2008-07-09 /pmc/articles/PMC2483994/ /pubmed/18613958 http://dx.doi.org/10.1186/1742-4690-5-61 Text en Copyright © 2008 Wu; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Commentary Wu, Yuntao The second chance story of HIV-1 DNA: Unintegrated? Not a problem! |
| title | The second chance story of HIV-1 DNA: Unintegrated? Not a problem! |
| title_full | The second chance story of HIV-1 DNA: Unintegrated? Not a problem! |
| title_fullStr | The second chance story of HIV-1 DNA: Unintegrated? Not a problem! |
| title_full_unstemmed | The second chance story of HIV-1 DNA: Unintegrated? Not a problem! |
| title_short | The second chance story of HIV-1 DNA: Unintegrated? Not a problem! |
| title_sort | second chance story of hiv-1 dna: unintegrated? not a problem! |
| topic | Commentary |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483994/ https://www.ncbi.nlm.nih.gov/pubmed/18613958 http://dx.doi.org/10.1186/1742-4690-5-61 |
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