Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat

BACKGROUND: During HIV-1 infection, the Tat protein plays a key role by transactivating the transcription of the HIV-1 proviral DNA. In addition, Tat induces apoptosis of non-infected T lymphocytes, leading to a massive loss of immune competence. This apoptosis is notably mediated by the interaction...

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Detalles Bibliográficos
Autores principales: Egelé, Caroline, Barbier, Pascale, Didier, Pascal, Piémont, Etienne, Allegro, Diane, Chaloin, Olivier, Muller, Sylviane, Peyrot, Vincent, Mély, Yves
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483996/
https://www.ncbi.nlm.nih.gov/pubmed/18613978
http://dx.doi.org/10.1186/1742-4690-5-62

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