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Temporary, but Essential Requirement of CD8(+) T Cells Early in the Pathogenesis of Diabetes in BB Rats as Revealed by Thymectomy and CD8 Depletion

Autoimmunity-prone BB rats demonstrate a T lymphocytopenia and abnormal T cell subset distribution. To test whether the life span of all T cells or only of certain subsets is reduced in BB rats, we thymectomised 8-week-old BB and PVG rats and subsequently assessed size and composition of the T cell...

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Detalles Bibliográficos
Autores principales:	Groen, Herman, Klatter, Flip, Pater, Jennie, Nieuwenhuis, Paul, Rozing, Jan
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2003
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2485407/ https://www.ncbi.nlm.nih.gov/pubmed/14768945 http://dx.doi.org/10.1080/10446670310001626508

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