Expression of the HPV16E7 Oncoprotein by Thymic Epithelium is Accompanied by Disrupted T Cell Maturation and a Failure of the Thymus to Involute with Age

Transgenic mice expressing the E7 protein of HPV16 from the keratin 14 promoter demonstrate increasing thymic hypertrophy with age. This hypertrophy is associated with increased absolute numbers of all thymocyte types, and with increased cortical and medullary cellularity. In the thymic medulla, inc...

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Detalles Bibliográficos
Autores principales: Malcolm, K. M., Gill, J., Leggatt, G. R., Boyd, R., Lambert, P., Frazer, I. H.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2485419/
https://www.ncbi.nlm.nih.gov/pubmed/14768939
http://dx.doi.org/10.1080/10446670310001626562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2485419/
https://www.ncbi.nlm.nih.gov/pubmed/14768939
http://dx.doi.org/10.1080/10446670310001626562

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