Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival

The nature of the “toxic gain of function” that results from amyotrophic lateral sclerosis (ALS)-, Parkinson-, and Alzheimer-related mutations is a matter of debate. As a result no adequate model of any neurodegenerative disease etiology exists. We demonstrate that two synergistic properties, namely...

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Detalles Bibliográficos
Autores principales: Wang, Qi, Johnson, Joshua L, Agar, Nathalie Y.R, Agar, Jeffrey N
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486295/
https://www.ncbi.nlm.nih.gov/pubmed/18666828
http://dx.doi.org/10.1371/journal.pbio.0060170

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