The Threat of Instability: Neurodegeneration Predicted by Protein Destabilization and Aggregation Propensity

A new method based on protein stability and aggregation propensity reveals a strong correlation between the properties of mutant Cu/Zn-superoxide dismutases associated with amyotrophic lateral sclerosis and patient survival.

Detalles Bibliográficos
Autor principal: Meiering, Elizabeth M
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486316/
https://www.ncbi.nlm.nih.gov/pubmed/18666836
http://dx.doi.org/10.1371/journal.pbio.0060193
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author Meiering, Elizabeth M
author_facet Meiering, Elizabeth M
author_sort Meiering, Elizabeth M
collection PubMed
description A new method based on protein stability and aggregation propensity reveals a strong correlation between the properties of mutant Cu/Zn-superoxide dismutases associated with amyotrophic lateral sclerosis and patient survival.
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spelling pubmed-24863162008-07-26 The Threat of Instability: Neurodegeneration Predicted by Protein Destabilization and Aggregation Propensity Meiering, Elizabeth M PLoS Biol Primer A new method based on protein stability and aggregation propensity reveals a strong correlation between the properties of mutant Cu/Zn-superoxide dismutases associated with amyotrophic lateral sclerosis and patient survival. Public Library of Science 2008-07 2008-07-29 /pmc/articles/PMC2486316/ /pubmed/18666836 http://dx.doi.org/10.1371/journal.pbio.0060193 Text en © 2008 Elizabeth M. Meiering. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Primer
Meiering, Elizabeth M
The Threat of Instability: Neurodegeneration Predicted by Protein Destabilization and Aggregation Propensity
title The Threat of Instability: Neurodegeneration Predicted by Protein Destabilization and Aggregation Propensity
title_full The Threat of Instability: Neurodegeneration Predicted by Protein Destabilization and Aggregation Propensity
title_fullStr The Threat of Instability: Neurodegeneration Predicted by Protein Destabilization and Aggregation Propensity
title_full_unstemmed The Threat of Instability: Neurodegeneration Predicted by Protein Destabilization and Aggregation Propensity
title_short The Threat of Instability: Neurodegeneration Predicted by Protein Destabilization and Aggregation Propensity
title_sort threat of instability: neurodegeneration predicted by protein destabilization and aggregation propensity
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486316/
https://www.ncbi.nlm.nih.gov/pubmed/18666836
http://dx.doi.org/10.1371/journal.pbio.0060193
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