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Synthesis, Structural, and Biological Studies of Some Schiff Bases and Their Metal Complexes
New bidentate or tridentate Schiff bases and their VO(II) and Co(II) complexes formed by the condensation of methyl isobutyl ketone with nicotinamide (mna)/2-amino-4-chlorophenol (map) and 2-hydroxy acetophenone with nicotinamide (han)/isoniazide (hai). Physicochemical characterization has been carr...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486403/ https://www.ncbi.nlm.nih.gov/pubmed/18670613 http://dx.doi.org/10.1155/2008/875410 |
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author | Mishra, A. P. Soni, Monika |
author_facet | Mishra, A. P. Soni, Monika |
author_sort | Mishra, A. P. |
collection | PubMed |
description | New bidentate or tridentate Schiff bases and their VO(II) and Co(II) complexes formed by the condensation of methyl isobutyl ketone with nicotinamide (mna)/2-amino-4-chlorophenol (map) and 2-hydroxy acetophenone with nicotinamide (han)/isoniazide (hai). Physicochemical characterization has been carried out to determine the structure of the complexes. The FAB mass and thermal data show degradation pattern of the complexes. XRD analysis reveals that all the studied complexes crystallize as tetragonal crystal system. Some of the complexes have been screened for their antimicrobial activity by the well diffusion technique using DMSO as solvent on different species of pathogenic bacteria/fungi, that is, E. coli, S. aureus, S. fecalis, A. niger, T. polysporum, and their antimicrobial potency have been discussed. It has been found that all the complexes are antimicrobially active and show higher activity than the free ligand. Metal chelation affects significantly the antimicrobial/bioactive behavior of the organic ligands. |
format | Text |
id | pubmed-2486403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-24864032008-07-31 Synthesis, Structural, and Biological Studies of Some Schiff Bases and Their Metal Complexes Mishra, A. P. Soni, Monika Met Based Drugs Research Article New bidentate or tridentate Schiff bases and their VO(II) and Co(II) complexes formed by the condensation of methyl isobutyl ketone with nicotinamide (mna)/2-amino-4-chlorophenol (map) and 2-hydroxy acetophenone with nicotinamide (han)/isoniazide (hai). Physicochemical characterization has been carried out to determine the structure of the complexes. The FAB mass and thermal data show degradation pattern of the complexes. XRD analysis reveals that all the studied complexes crystallize as tetragonal crystal system. Some of the complexes have been screened for their antimicrobial activity by the well diffusion technique using DMSO as solvent on different species of pathogenic bacteria/fungi, that is, E. coli, S. aureus, S. fecalis, A. niger, T. polysporum, and their antimicrobial potency have been discussed. It has been found that all the complexes are antimicrobially active and show higher activity than the free ligand. Metal chelation affects significantly the antimicrobial/bioactive behavior of the organic ligands. Hindawi Publishing Corporation 2008 2008-07-27 /pmc/articles/PMC2486403/ /pubmed/18670613 http://dx.doi.org/10.1155/2008/875410 Text en Copyright © 2008 A. P. Mishra and M. Soni. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mishra, A. P. Soni, Monika Synthesis, Structural, and Biological Studies of Some Schiff Bases and Their Metal Complexes |
title | Synthesis, Structural, and Biological Studies of Some Schiff Bases and Their Metal Complexes |
title_full | Synthesis, Structural, and Biological Studies of Some Schiff Bases and Their Metal Complexes |
title_fullStr | Synthesis, Structural, and Biological Studies of Some Schiff Bases and Their Metal Complexes |
title_full_unstemmed | Synthesis, Structural, and Biological Studies of Some Schiff Bases and Their Metal Complexes |
title_short | Synthesis, Structural, and Biological Studies of Some Schiff Bases and Their Metal Complexes |
title_sort | synthesis, structural, and biological studies of some schiff bases and their metal complexes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486403/ https://www.ncbi.nlm.nih.gov/pubmed/18670613 http://dx.doi.org/10.1155/2008/875410 |
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