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A variant in the sonic hedgehog regulatory sequence (ZRS) is associated with triphalangeal thumb and deregulates expression in the developing limb
A locus for triphalangeal thumb, variably associated with pre-axial polydactyly, was previously identified in the zone of polarizing activity regulatory sequence (ZRS), a long range limb-specific enhancer of the Sonic Hedgehog (SHH) gene at human chromosome 7q36.3. Here, we demonstrate that a 295T&g...
Autores principales: | Furniss, Dominic, Lettice, Laura A., Taylor, Indira B., Critchley, Paul S., Giele, Henk, Hill, Robert E., Wilkie, Andrew O.M. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486440/ https://www.ncbi.nlm.nih.gov/pubmed/18463159 http://dx.doi.org/10.1093/hmg/ddn141 |
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