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Trifluoromethyl ethers – synthesis and properties of an unusual substituent

After nitrogen, fluorine is probably the next most favorite hetero-atom for incorporation into small molecules in life science-oriented research. This review focuses on a particular fluorinated substituent, the trifluoromethoxy group, which is finding increased utility as a substituent in bioactives...

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Autores principales: Leroux, Frédéric R, Manteau, Baptiste, Vors, Jean-Pierre, Pazenok, Sergiy
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486484/
https://www.ncbi.nlm.nih.gov/pubmed/18941485
http://dx.doi.org/10.3762/bjoc.4.13
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author Leroux, Frédéric R
Manteau, Baptiste
Vors, Jean-Pierre
Pazenok, Sergiy
author_facet Leroux, Frédéric R
Manteau, Baptiste
Vors, Jean-Pierre
Pazenok, Sergiy
author_sort Leroux, Frédéric R
collection PubMed
description After nitrogen, fluorine is probably the next most favorite hetero-atom for incorporation into small molecules in life science-oriented research. This review focuses on a particular fluorinated substituent, the trifluoromethoxy group, which is finding increased utility as a substituent in bioactives, but it is still perhaps the least well understood fluorine substituent in currency. The present review will give an overview of the synthesis, properties and reactivity of this important substituent.
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spelling pubmed-24864842008-10-20 Trifluoromethyl ethers – synthesis and properties of an unusual substituent Leroux, Frédéric R Manteau, Baptiste Vors, Jean-Pierre Pazenok, Sergiy Beilstein J Org Chem Review After nitrogen, fluorine is probably the next most favorite hetero-atom for incorporation into small molecules in life science-oriented research. This review focuses on a particular fluorinated substituent, the trifluoromethoxy group, which is finding increased utility as a substituent in bioactives, but it is still perhaps the least well understood fluorine substituent in currency. The present review will give an overview of the synthesis, properties and reactivity of this important substituent. Beilstein-Institut 2008-04-29 /pmc/articles/PMC2486484/ /pubmed/18941485 http://dx.doi.org/10.3762/bjoc.4.13 Text en Copyright © 2008, Leroux et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Review
Leroux, Frédéric R
Manteau, Baptiste
Vors, Jean-Pierre
Pazenok, Sergiy
Trifluoromethyl ethers – synthesis and properties of an unusual substituent
title Trifluoromethyl ethers – synthesis and properties of an unusual substituent
title_full Trifluoromethyl ethers – synthesis and properties of an unusual substituent
title_fullStr Trifluoromethyl ethers – synthesis and properties of an unusual substituent
title_full_unstemmed Trifluoromethyl ethers – synthesis and properties of an unusual substituent
title_short Trifluoromethyl ethers – synthesis and properties of an unusual substituent
title_sort trifluoromethyl ethers – synthesis and properties of an unusual substituent
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486484/
https://www.ncbi.nlm.nih.gov/pubmed/18941485
http://dx.doi.org/10.3762/bjoc.4.13
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