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Trifluoromethyl ethers – synthesis and properties of an unusual substituent
After nitrogen, fluorine is probably the next most favorite hetero-atom for incorporation into small molecules in life science-oriented research. This review focuses on a particular fluorinated substituent, the trifluoromethoxy group, which is finding increased utility as a substituent in bioactives...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Beilstein-Institut
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486484/ https://www.ncbi.nlm.nih.gov/pubmed/18941485 http://dx.doi.org/10.3762/bjoc.4.13 |
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author | Leroux, Frédéric R Manteau, Baptiste Vors, Jean-Pierre Pazenok, Sergiy |
author_facet | Leroux, Frédéric R Manteau, Baptiste Vors, Jean-Pierre Pazenok, Sergiy |
author_sort | Leroux, Frédéric R |
collection | PubMed |
description | After nitrogen, fluorine is probably the next most favorite hetero-atom for incorporation into small molecules in life science-oriented research. This review focuses on a particular fluorinated substituent, the trifluoromethoxy group, which is finding increased utility as a substituent in bioactives, but it is still perhaps the least well understood fluorine substituent in currency. The present review will give an overview of the synthesis, properties and reactivity of this important substituent. |
format | Text |
id | pubmed-2486484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-24864842008-10-20 Trifluoromethyl ethers – synthesis and properties of an unusual substituent Leroux, Frédéric R Manteau, Baptiste Vors, Jean-Pierre Pazenok, Sergiy Beilstein J Org Chem Review After nitrogen, fluorine is probably the next most favorite hetero-atom for incorporation into small molecules in life science-oriented research. This review focuses on a particular fluorinated substituent, the trifluoromethoxy group, which is finding increased utility as a substituent in bioactives, but it is still perhaps the least well understood fluorine substituent in currency. The present review will give an overview of the synthesis, properties and reactivity of this important substituent. Beilstein-Institut 2008-04-29 /pmc/articles/PMC2486484/ /pubmed/18941485 http://dx.doi.org/10.3762/bjoc.4.13 Text en Copyright © 2008, Leroux et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Review Leroux, Frédéric R Manteau, Baptiste Vors, Jean-Pierre Pazenok, Sergiy Trifluoromethyl ethers – synthesis and properties of an unusual substituent |
title | Trifluoromethyl ethers – synthesis and properties of an unusual substituent |
title_full | Trifluoromethyl ethers – synthesis and properties of an unusual substituent |
title_fullStr | Trifluoromethyl ethers – synthesis and properties of an unusual substituent |
title_full_unstemmed | Trifluoromethyl ethers – synthesis and properties of an unusual substituent |
title_short | Trifluoromethyl ethers – synthesis and properties of an unusual substituent |
title_sort | trifluoromethyl ethers – synthesis and properties of an unusual substituent |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486484/ https://www.ncbi.nlm.nih.gov/pubmed/18941485 http://dx.doi.org/10.3762/bjoc.4.13 |
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