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Origin of the blood hyperserotonemia of autism
BACKGROUND: Research in the last fifty years has shown that many autistic individuals have elevated serotonin (5-hydroxytryptamine, 5-HT) levels in blood platelets. This phenomenon, known as the platelet hyperserotonemia of autism, is considered to be one of the most well-replicated findings in biol...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488334/ https://www.ncbi.nlm.nih.gov/pubmed/18498654 http://dx.doi.org/10.1186/1742-4682-5-10 |
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author | Janušonis, Skirmantas |
author_facet | Janušonis, Skirmantas |
author_sort | Janušonis, Skirmantas |
collection | PubMed |
description | BACKGROUND: Research in the last fifty years has shown that many autistic individuals have elevated serotonin (5-hydroxytryptamine, 5-HT) levels in blood platelets. This phenomenon, known as the platelet hyperserotonemia of autism, is considered to be one of the most well-replicated findings in biological psychiatry. Its replicability suggests that many of the genes involved in autism affect a small number of biological networks. These networks may also play a role in the early development of the autistic brain. RESULTS: We developed an equation that allows calculation of platelet 5-HT concentration as a function of measurable biological parameters. It also provides information about the sensitivity of platelet 5-HT levels to each of the parameters and their interactions. CONCLUSION: The model yields platelet 5-HT concentrations that are consistent with values reported in experimental studies. If the parameters are considered independent, the model predicts that platelet 5-HT levels should be sensitive to changes in the platelet 5-HT uptake rate constant, the proportion of free 5-HT cleared in the liver and lungs, the gut 5-HT production rate and its regulation, and the volume of the gut wall. Linear and non-linear interactions among these and other parameters are specified in the equation, which may facilitate the design and interpretation of experimental studies. |
format | Text |
id | pubmed-2488334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-24883342008-07-29 Origin of the blood hyperserotonemia of autism Janušonis, Skirmantas Theor Biol Med Model Research BACKGROUND: Research in the last fifty years has shown that many autistic individuals have elevated serotonin (5-hydroxytryptamine, 5-HT) levels in blood platelets. This phenomenon, known as the platelet hyperserotonemia of autism, is considered to be one of the most well-replicated findings in biological psychiatry. Its replicability suggests that many of the genes involved in autism affect a small number of biological networks. These networks may also play a role in the early development of the autistic brain. RESULTS: We developed an equation that allows calculation of platelet 5-HT concentration as a function of measurable biological parameters. It also provides information about the sensitivity of platelet 5-HT levels to each of the parameters and their interactions. CONCLUSION: The model yields platelet 5-HT concentrations that are consistent with values reported in experimental studies. If the parameters are considered independent, the model predicts that platelet 5-HT levels should be sensitive to changes in the platelet 5-HT uptake rate constant, the proportion of free 5-HT cleared in the liver and lungs, the gut 5-HT production rate and its regulation, and the volume of the gut wall. Linear and non-linear interactions among these and other parameters are specified in the equation, which may facilitate the design and interpretation of experimental studies. BioMed Central 2008-05-22 /pmc/articles/PMC2488334/ /pubmed/18498654 http://dx.doi.org/10.1186/1742-4682-5-10 Text en Copyright © 2008 Janušonis; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Janušonis, Skirmantas Origin of the blood hyperserotonemia of autism |
title | Origin of the blood hyperserotonemia of autism |
title_full | Origin of the blood hyperserotonemia of autism |
title_fullStr | Origin of the blood hyperserotonemia of autism |
title_full_unstemmed | Origin of the blood hyperserotonemia of autism |
title_short | Origin of the blood hyperserotonemia of autism |
title_sort | origin of the blood hyperserotonemia of autism |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488334/ https://www.ncbi.nlm.nih.gov/pubmed/18498654 http://dx.doi.org/10.1186/1742-4682-5-10 |
work_keys_str_mv | AT janusonisskirmantas originofthebloodhyperserotonemiaofautism |