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Membrane fusion

Subcellular compartmentalization, cell growth, hormone secretion and neurotransmission require rapid, targeted, and regulated membrane fusion. Fusion entails extensive lipid rearrangements by two apposed (docked) membrane vesicles, joining their membrane proteins and lipids and mixing their luminal...

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Detalles Bibliográficos
Autores principales: Wickner, William, Schekman, Randy
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488960/
https://www.ncbi.nlm.nih.gov/pubmed/18618939
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author Wickner, William
Schekman, Randy
author_facet Wickner, William
Schekman, Randy
author_sort Wickner, William
collection PubMed
description Subcellular compartmentalization, cell growth, hormone secretion and neurotransmission require rapid, targeted, and regulated membrane fusion. Fusion entails extensive lipid rearrangements by two apposed (docked) membrane vesicles, joining their membrane proteins and lipids and mixing their luminal contents without lysis. Fusion of membranes in the secretory pathway involves Rab GTPases; their bound ‘effector’ proteins, which mediate downstream steps; SNARE proteins, which can ‘snare’ each other, in cis (bound to one membrane) or in trans (anchored to apposed membranes); and SNARE-associated proteins (SM proteins; NSF or Sec18p; SNAP or Sec17p; and others) cooperating with specific lipids to catalyze fusion. In contrast, mitochondrial and cell-cell fusion events are regulated by and use distinct catalysts.
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spelling pubmed-24889602009-01-01 Membrane fusion Wickner, William Schekman, Randy Nat Struct Mol Biol Article Subcellular compartmentalization, cell growth, hormone secretion and neurotransmission require rapid, targeted, and regulated membrane fusion. Fusion entails extensive lipid rearrangements by two apposed (docked) membrane vesicles, joining their membrane proteins and lipids and mixing their luminal contents without lysis. Fusion of membranes in the secretory pathway involves Rab GTPases; their bound ‘effector’ proteins, which mediate downstream steps; SNARE proteins, which can ‘snare’ each other, in cis (bound to one membrane) or in trans (anchored to apposed membranes); and SNARE-associated proteins (SM proteins; NSF or Sec18p; SNAP or Sec17p; and others) cooperating with specific lipids to catalyze fusion. In contrast, mitochondrial and cell-cell fusion events are regulated by and use distinct catalysts. 2008-07 /pmc/articles/PMC2488960/ /pubmed/18618939 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Wickner, William
Schekman, Randy
Membrane fusion
title Membrane fusion
title_full Membrane fusion
title_fullStr Membrane fusion
title_full_unstemmed Membrane fusion
title_short Membrane fusion
title_sort membrane fusion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488960/
https://www.ncbi.nlm.nih.gov/pubmed/18618939
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