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Structural analysis of urate oxidase in complex with its natural substrate inhibited by cyanide: Mechanistic implications
BACKGROUND: Urate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid and gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide, in the absence of cofactor or particular metal cation. The functional enzyme is a homo-tetramer with four active sites located at dimeric inter...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490695/ https://www.ncbi.nlm.nih.gov/pubmed/18638417 http://dx.doi.org/10.1186/1472-6807-8-32 |