Expression and functional analysis of Nr2e3, a photoreceptor-specific nuclear receptor, suggest common mechanisms in retinal development between avians and mammals

The photoreceptor-specific nuclear receptor (PNR; Nr2e3) is a transcription factor important for retinal development. We report here the identification and expression analysis of the avian Nr2e3. Nr2e3 mRNA is expressed in the photoreceptor layer of the neural retina during early stages of chick emb...

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Detalles Bibliográficos
Autores principales: Kobayashi, Mime, Hara, Kenji, Yu, Ruth T., Yasuda, Kunio
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490731/
https://www.ncbi.nlm.nih.gov/pubmed/18592265
http://dx.doi.org/10.1007/s00427-008-0232-1
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author Kobayashi, Mime
Hara, Kenji
Yu, Ruth T.
Yasuda, Kunio
author_facet Kobayashi, Mime
Hara, Kenji
Yu, Ruth T.
Yasuda, Kunio
author_sort Kobayashi, Mime
collection PubMed
description The photoreceptor-specific nuclear receptor (PNR; Nr2e3) is a transcription factor important for retinal development. We report here the identification and expression analysis of the avian Nr2e3. Nr2e3 mRNA is expressed in the photoreceptor layer of the neural retina during early stages of chick embryogenesis. Its temporal expression is distinct from that of a related nuclear receptor, Tlx. Chick Nr2e3 recognizes and binds to the same target DNA sequence as its vertebrate orthologs. Functional assays revealed that chick Nr2e3 acts as a transcriptional repressor. Our results suggest that Nr2e3 plays a common role in retinal development in vertebrates.
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spelling pubmed-24907312008-07-30 Expression and functional analysis of Nr2e3, a photoreceptor-specific nuclear receptor, suggest common mechanisms in retinal development between avians and mammals Kobayashi, Mime Hara, Kenji Yu, Ruth T. Yasuda, Kunio Dev Genes Evol Short Communication The photoreceptor-specific nuclear receptor (PNR; Nr2e3) is a transcription factor important for retinal development. We report here the identification and expression analysis of the avian Nr2e3. Nr2e3 mRNA is expressed in the photoreceptor layer of the neural retina during early stages of chick embryogenesis. Its temporal expression is distinct from that of a related nuclear receptor, Tlx. Chick Nr2e3 recognizes and binds to the same target DNA sequence as its vertebrate orthologs. Functional assays revealed that chick Nr2e3 acts as a transcriptional repressor. Our results suggest that Nr2e3 plays a common role in retinal development in vertebrates. Springer-Verlag 2008-07-01 2008 /pmc/articles/PMC2490731/ /pubmed/18592265 http://dx.doi.org/10.1007/s00427-008-0232-1 Text en © The Author(s) 2008 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Short Communication
Kobayashi, Mime
Hara, Kenji
Yu, Ruth T.
Yasuda, Kunio
Expression and functional analysis of Nr2e3, a photoreceptor-specific nuclear receptor, suggest common mechanisms in retinal development between avians and mammals
title Expression and functional analysis of Nr2e3, a photoreceptor-specific nuclear receptor, suggest common mechanisms in retinal development between avians and mammals
title_full Expression and functional analysis of Nr2e3, a photoreceptor-specific nuclear receptor, suggest common mechanisms in retinal development between avians and mammals
title_fullStr Expression and functional analysis of Nr2e3, a photoreceptor-specific nuclear receptor, suggest common mechanisms in retinal development between avians and mammals
title_full_unstemmed Expression and functional analysis of Nr2e3, a photoreceptor-specific nuclear receptor, suggest common mechanisms in retinal development between avians and mammals
title_short Expression and functional analysis of Nr2e3, a photoreceptor-specific nuclear receptor, suggest common mechanisms in retinal development between avians and mammals
title_sort expression and functional analysis of nr2e3, a photoreceptor-specific nuclear receptor, suggest common mechanisms in retinal development between avians and mammals
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490731/
https://www.ncbi.nlm.nih.gov/pubmed/18592265
http://dx.doi.org/10.1007/s00427-008-0232-1
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AT yasudakunio expressionandfunctionalanalysisofnr2e3aphotoreceptorspecificnuclearreceptorsuggestcommonmechanismsinretinaldevelopmentbetweenaviansandmammals

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