Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells

In the search of facile and efficient methods for cellular delivery of peptide nucleic acids (PNA), we have synthesized PNAs conjugated to oligophosphonates via phosphonate glutamine and bis-phosphonate lysine amino acid derivatives thereby introducing up to twelve phosphonate moieties into a PNA ol...

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Detalles Bibliográficos
Autores principales: Shiraishi, Takehiko, Hamzavi, Ramin, Nielsen, Peter E.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490735/
https://www.ncbi.nlm.nih.gov/pubmed/18596083
http://dx.doi.org/10.1093/nar/gkn401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490735/
https://www.ncbi.nlm.nih.gov/pubmed/18596083
http://dx.doi.org/10.1093/nar/gkn401

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