Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase

Loss of the RecQ helicase WRN protein causes the cancer-prone progeroid disorder Werner syndrome (WS). WS cells exhibit defects in DNA replication and telomere preservation. The telomeric single-stranded binding protein POT1 stimulates WRN helicase to unwind longer telomeric duplexes that are otherw...

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Detalles Bibliográficos
Autores principales: Sowd, Gregory, Lei, Ming, Opresko, Patricia L.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490755/
https://www.ncbi.nlm.nih.gov/pubmed/18583366
http://dx.doi.org/10.1093/nar/gkn385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490755/
https://www.ncbi.nlm.nih.gov/pubmed/18583366
http://dx.doi.org/10.1093/nar/gkn385

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