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Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase
Loss of the RecQ helicase WRN protein causes the cancer-prone progeroid disorder Werner syndrome (WS). WS cells exhibit defects in DNA replication and telomere preservation. The telomeric single-stranded binding protein POT1 stimulates WRN helicase to unwind longer telomeric duplexes that are otherw...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490755/ https://www.ncbi.nlm.nih.gov/pubmed/18583366 http://dx.doi.org/10.1093/nar/gkn385 |