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Dendritic cell vaccination and immune monitoring
We exploited dendritic cells (DC) to vaccinate melanoma patients. We recently demonstrated a statistical significant correlation between favorable clinical outcome and the presence of vaccine-related tumor antigen-specific T cells in delayed type hypersensitivity (DTH) skin biopsies. However, favora...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
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Springer-Verlag
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491428/ https://www.ncbi.nlm.nih.gov/pubmed/18618110 http://dx.doi.org/10.1007/s00262-008-0553-y |
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| author | Aarntzen, E. H. J. G. Figdor, C. G. Adema, G. J. Punt, C. J. A. de Vries, I. J. M. |
| author_facet | Aarntzen, E. H. J. G. Figdor, C. G. Adema, G. J. Punt, C. J. A. de Vries, I. J. M. |
| author_sort | Aarntzen, E. H. J. G. |
| collection | PubMed |
| description | We exploited dendritic cells (DC) to vaccinate melanoma patients. We recently demonstrated a statistical significant correlation between favorable clinical outcome and the presence of vaccine-related tumor antigen-specific T cells in delayed type hypersensitivity (DTH) skin biopsies. However, favorable clinical outcome is only observed in a minority of the treated patients. Therefore, it is obvious that current DC-based protocols need to be improved. For this reason, we study in small proof of principle trials the fate, interactions and effectiveness of the injected DC. |
| format | Text |
| id | pubmed-2491428 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2008 |
| publisher | Springer-Verlag |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-24914282008-07-30 Dendritic cell vaccination and immune monitoring Aarntzen, E. H. J. G. Figdor, C. G. Adema, G. J. Punt, C. J. A. de Vries, I. J. M. Cancer Immunol Immunother Symposium Paper We exploited dendritic cells (DC) to vaccinate melanoma patients. We recently demonstrated a statistical significant correlation between favorable clinical outcome and the presence of vaccine-related tumor antigen-specific T cells in delayed type hypersensitivity (DTH) skin biopsies. However, favorable clinical outcome is only observed in a minority of the treated patients. Therefore, it is obvious that current DC-based protocols need to be improved. For this reason, we study in small proof of principle trials the fate, interactions and effectiveness of the injected DC. Springer-Verlag 2008-07-10 2008 /pmc/articles/PMC2491428/ /pubmed/18618110 http://dx.doi.org/10.1007/s00262-008-0553-y Text en © The Author(s) 2008 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
| spellingShingle | Symposium Paper Aarntzen, E. H. J. G. Figdor, C. G. Adema, G. J. Punt, C. J. A. de Vries, I. J. M. Dendritic cell vaccination and immune monitoring |
| title | Dendritic cell vaccination and immune monitoring |
| title_full | Dendritic cell vaccination and immune monitoring |
| title_fullStr | Dendritic cell vaccination and immune monitoring |
| title_full_unstemmed | Dendritic cell vaccination and immune monitoring |
| title_short | Dendritic cell vaccination and immune monitoring |
| title_sort | dendritic cell vaccination and immune monitoring |
| topic | Symposium Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491428/ https://www.ncbi.nlm.nih.gov/pubmed/18618110 http://dx.doi.org/10.1007/s00262-008-0553-y |
| work_keys_str_mv | AT aarntzenehjg dendriticcellvaccinationandimmunemonitoring AT figdorcg dendriticcellvaccinationandimmunemonitoring AT ademagj dendriticcellvaccinationandimmunemonitoring AT puntcja dendriticcellvaccinationandimmunemonitoring AT devriesijm dendriticcellvaccinationandimmunemonitoring |