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Conservation and Variability of Dengue Virus Proteins: Implications for Vaccine Design

BACKGROUND: Genetic variation and rapid evolution are hallmarks of RNA viruses, the result of high mutation rates in RNA replication and selection of mutants that enhance viral adaptation, including the escape from host immune responses. Variability is uneven across the genome because mutations resu...

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Detalles Bibliográficos
Autores principales:	Khan, Asif M., Miotto, Olivo, Nascimento, Eduardo J. M., Srinivasan, K. N., Heiny, A. T., Zhang, Guang Lan, Marques, E. T., Tan, Tin Wee, Brusic, Vladimir, Salmon, Jerome, August, J. Thomas
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491585/ https://www.ncbi.nlm.nih.gov/pubmed/18698358 http://dx.doi.org/10.1371/journal.pntd.0000272

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