Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway

The Human papillomavirus plays an important role in the initiation and progression of cervical cancer. However, it is a necessary but not sufficient cause to develop invasive carcinoma; hence, other factors are required in the pathogenesis of this malignancy. In this review we explore the hypothesis...

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Detalles Bibliográficos
Autores principales: Perez-Plasencia, Carlos, Duenas-Gonzalez, Alfonso, Alatorre-Tavera, Brenda
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491599/
https://www.ncbi.nlm.nih.gov/pubmed/18606007
http://dx.doi.org/10.1186/1755-7682-1-10
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author Perez-Plasencia, Carlos
Duenas-Gonzalez, Alfonso
Alatorre-Tavera, Brenda
author_facet Perez-Plasencia, Carlos
Duenas-Gonzalez, Alfonso
Alatorre-Tavera, Brenda
author_sort Perez-Plasencia, Carlos
collection PubMed
description The Human papillomavirus plays an important role in the initiation and progression of cervical cancer. However, it is a necessary but not sufficient cause to develop invasive carcinoma; hence, other factors are required in the pathogenesis of this malignancy. In this review we explore the hypothesis of the deregulation of wnt/β-catenin signaling pathway as a "second hit" required to develop cervical cancer.
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spelling pubmed-24915992008-07-31 Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway Perez-Plasencia, Carlos Duenas-Gonzalez, Alfonso Alatorre-Tavera, Brenda Int Arch Med Review The Human papillomavirus plays an important role in the initiation and progression of cervical cancer. However, it is a necessary but not sufficient cause to develop invasive carcinoma; hence, other factors are required in the pathogenesis of this malignancy. In this review we explore the hypothesis of the deregulation of wnt/β-catenin signaling pathway as a "second hit" required to develop cervical cancer. BioMed Central 2008-07-07 /pmc/articles/PMC2491599/ /pubmed/18606007 http://dx.doi.org/10.1186/1755-7682-1-10 Text en Copyright © 2008 Perez-Plasencia et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Perez-Plasencia, Carlos
Duenas-Gonzalez, Alfonso
Alatorre-Tavera, Brenda
Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway
title Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway
title_full Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway
title_fullStr Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway
title_full_unstemmed Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway
title_short Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway
title_sort second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491599/
https://www.ncbi.nlm.nih.gov/pubmed/18606007
http://dx.doi.org/10.1186/1755-7682-1-10
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