APOBEC3G encapsidation into HIV-1 virions: which RNA is it?

APOBEC3G is a cytidine deaminase with potent antiviral activity. The protein deaminates single-stranded DNA but is known to bind cellular and viral RNAs. There is increasing evidence that RNA binding of APOBEC3G is important for packaging into viral particles. However, there is no consensus yet on t...

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Detalles Bibliográficos
Autores principales: Strebel, Klaus, Khan, Mohammad A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491656/
https://www.ncbi.nlm.nih.gov/pubmed/18597677
http://dx.doi.org/10.1186/1742-4690-5-55
Descripción
Sumario:APOBEC3G is a cytidine deaminase with potent antiviral activity. The protein deaminates single-stranded DNA but is known to bind cellular and viral RNAs. There is increasing evidence that RNA binding of APOBEC3G is important for packaging into viral particles. However, there is no consensus yet on the type of RNA involved.

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