Cargando…

Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency

AIMS: Deletion of the transcription factor Cited2 causes penetrant and phenotypically heterogenous cardiovascular and laterality defects and adrenal agenesis. Heterozygous human CITED2 mutation is associated with congenital heart disease, suggesting haploinsufficiency. Cited2 functions partly via a...

Descripción completa

Detalles Bibliográficos
Autores principales:	MacDonald, Simon T., Bamforth, Simon D., Chen, Chiann-Mun, Farthing, Cassandra R., Franklyn, Angela, Broadbent, Carol, Schneider, Jürgen E., Saga, Yumiko, Lewandoski, Mark, Bhattacharya, Shoumo
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492730/ https://www.ncbi.nlm.nih.gov/pubmed/18440989 http://dx.doi.org/10.1093/cvr/cvn101

Ejemplares similares

A cell-autonomous role of Cited2 in controlling myocardial and coronary vascular development
por: MacDonald, Simon T., et al.
Publicado: (2013)

A Novel Role for Transcription Factor Lmo4 in Thymus Development Through Genetic Interaction with Cited2
por: Michell, Anna C, et al.
Publicado: (2010)

Functional Significance of SRJ Domain Mutations in CITED2
por: Chen, Chiann-mun, et al.
Publicado: (2012)

Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique
por: Schneider, Jürgen E, et al.
Publicado: (2004)

Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells
por: Kranc, Kamil R., et al.
Publicado: (2009)

A Comparison of Exogenous Promoter Activity at the ROSA26 Locus Using a PhiC31 Integrase Mediated Cassette Exchange Approach in Mouse ES Cells
por: Chen, Chiann-mun, et al.
Publicado: (2011)

Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype
por: Khasawneh, Ramada R., et al.
Publicado: (2021)

Maternal high-fat diet interacts with embryonic Cited2 genotype to reduce Pitx2c expression and enhance penetrance of left–right patterning defects
por: Bentham, Jamie, et al.
Publicado: (2010)

Early Embryonic Expression of AP-2α Is Critical for Cardiovascular Development
por: Johnson, Amy-Leigh, et al.
Publicado: (2020)

Rat epiblast-derived stem cells recapitulate the attributes of pre-gastrulation epiblast
por: Masamsetti, V. Pragathi, et al.
Publicado: (2023)

Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation
por: Basilicata, M. Felicia, et al.
Publicado: (2016)

Epiblast Ground State Is Controlled by Canonical Wnt/β-Catenin Signaling in the Postimplantation Mouse Embryo and Epiblast Stem Cells
por: Sumi, Tomoyuki, et al.
Publicado: (2013)

Epiblast cells CLASP onto the basement membrane
por: Short, Ben
Publicado: (2013)

Tracking and ablating subpopulations of epiblast cells in the chick embryo
por: Gerhart, Jacquelyn, et al.
Publicado: (2008)

Induction of Primordial Germ Cells from Pluripotent Epiblast
por: Ying, Ying, et al.
Publicado: (2002)

Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells
por: Khoa, Le Tran Phuc, et al.
Publicado: (2016)

Generation of Mouse Parthenogenetic Epiblast Stem Cells and Their Imprinting Patterns
por: Seo, Bong Jong, et al.
Publicado: (2019)

Trophectoderm mechanics direct epiblast shape upon embryo implantation
por: Weberling, Antonia, et al.
Publicado: (2021)

Human naive epiblast cells possess unrestricted lineage potential
por: Guo, Ge, et al.
Publicado: (2021)

A Simple and Robust Method for Establishing Homogeneous Mouse Epiblast Stem Cell Lines by Wnt Inhibition
por: Sugimoto, Michihiko, et al.
Publicado: (2015)

Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma
por: Pohler, Elizabeth, et al.
Publicado: (2012)

Cellular Heterogeneity During Embryonic Stem Cell Differentiation to Epiblast Stem Cells is Revealed by the ShcD/RaLP Adaptor Protein
por: Turco, Margherita Y, et al.
Publicado: (2012)

Spatially resolved cell polarity proteomics of a human epiblast model
por: Wang, Sicong, et al.
Publicado: (2021)

YAP establishes epiblast responsiveness to inductive signals for germ cell fate
por: Kagiwada, Saya, et al.
Publicado: (2021)

An in vitro stem cell model of human epiblast and yolk sac interaction
por: Mackinlay, Kirsty ML, et al.
Publicado: (2021)

Generation and characterization of stable pig pregastrulation epiblast stem cell lines
por: Zhi, Minglei, et al.
Publicado: (2021)

AMPK activation reverts mouse epiblast stem cells to naive state
por: Liu, Yajing, et al.
Publicado: (2021)

NANOG initiates epiblast fate through the coordination of pluripotency genes expression
por: Allègre, Nicolas, et al.
Publicado: (2022)

Progression of the pluripotent epiblast depends upon the NMD factor UPF2
por: Chousal, Jennifer N., et al.
Publicado: (2022)

MyoD-positive epiblast cells regulate skeletal muscle differentiation in the embryo
por: Gerhart, Jacquelyn, et al.
Publicado: (2006)

Epiblast Stem Cell-Based System Reveals Reprogramming Synergy of Germline Factors
por: Gillich, Astrid, et al.
Publicado: (2012)

E-Cadherin Promotes Incorporation of Mouse Epiblast Stem Cells into Normal Development
por: Ohtsuka, Satoshi, et al.
Publicado: (2012)

Rnf12/RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast
por: Shin, JongDae, et al.
Publicado: (2014)

Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex
por: Nakaya, Yukiko, et al.
Publicado: (2013)

Successful Reprogramming of Epiblast Stem Cells by Blocking Nuclear Localization of β-Catenin
por: Murayama, Hideyuki, et al.
Publicado: (2014)

Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells
por: Liu, Chang, et al.
Publicado: (2018)

The epigenetic modifier Fam208a is required to maintain epiblast cell fitness
por: Bhargava, Shohag, et al.
Publicado: (2017)

Human ES Cell Culture Conditions Fail to Preserve the Mouse Epiblast State
por: Devika, A. S., et al.
Publicado: (2021)

Deciphering epiblast lumenogenesis reveals proamniotic cavity control of embryo growth and patterning
por: Kim, Yung Su, et al.
Publicado: (2021)

Reprogramming epiblast stem cells into pre-implantation blastocyst cell-like cells
por: Tomoda, Kiichiro, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6phqarrhikassccj937ev2jl2d