Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

Recently, two novel concepts have emerged in cancer biology: the role of so-called “cancer stem cells” in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells. Using a mammary tumor progression model, we show t...

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Detalles Bibliográficos
Autores principales: Morel, Anne-Pierre, Lièvre, Marjory, Thomas, Clémence, Hinkal, George, Ansieau, Stéphane, Puisieux, Alain
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492808/
https://www.ncbi.nlm.nih.gov/pubmed/18682804
http://dx.doi.org/10.1371/journal.pone.0002888
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author Morel, Anne-Pierre
Lièvre, Marjory
Thomas, Clémence
Hinkal, George
Ansieau, Stéphane
Puisieux, Alain
author_facet Morel, Anne-Pierre
Lièvre, Marjory
Thomas, Clémence
Hinkal, George
Ansieau, Stéphane
Puisieux, Alain
author_sort Morel, Anne-Pierre
collection PubMed
description Recently, two novel concepts have emerged in cancer biology: the role of so-called “cancer stem cells” in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells. Using a mammary tumor progression model, we show that cells possessing both stem and tumorigenic characteristics of “cancer stem cells” can be derived from human mammary epithelial cells following the activation of the Ras-MAPK pathway. The acquisition of these stem and tumorigenic characters is driven by EMT induction.
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spelling pubmed-24928082008-08-06 Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition Morel, Anne-Pierre Lièvre, Marjory Thomas, Clémence Hinkal, George Ansieau, Stéphane Puisieux, Alain PLoS One Research Article Recently, two novel concepts have emerged in cancer biology: the role of so-called “cancer stem cells” in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells. Using a mammary tumor progression model, we show that cells possessing both stem and tumorigenic characteristics of “cancer stem cells” can be derived from human mammary epithelial cells following the activation of the Ras-MAPK pathway. The acquisition of these stem and tumorigenic characters is driven by EMT induction. Public Library of Science 2008-08-06 /pmc/articles/PMC2492808/ /pubmed/18682804 http://dx.doi.org/10.1371/journal.pone.0002888 Text en Morel et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Morel, Anne-Pierre
Lièvre, Marjory
Thomas, Clémence
Hinkal, George
Ansieau, Stéphane
Puisieux, Alain
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
title Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
title_full Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
title_fullStr Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
title_full_unstemmed Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
title_short Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
title_sort generation of breast cancer stem cells through epithelial-mesenchymal transition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492808/
https://www.ncbi.nlm.nih.gov/pubmed/18682804
http://dx.doi.org/10.1371/journal.pone.0002888
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