Cargando…

Dominant negative mutant Cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat

BACKGROUND: The positive transcription elongation factor b (P-TEFb) is an essential cellular co-factor for the transcription of the human immunodeficiency virus type 1 (HIV-1). The cyclin T1 (CycT1) subunit of P-TEFb associates with a viral protein, Tat, at the transactivation response element (TAR)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jadlowsky, Julie K, Nojima, Masanori, Schulte, Antje, Geyer, Matthias, Okamoto, Takashi, Fujinaga, Koh
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492875/ https://www.ncbi.nlm.nih.gov/pubmed/18620576 http://dx.doi.org/10.1186/1742-4690-5-63

Ejemplares similares

Insights into the activation of transcription elongation by lentiviruses: structure of the Cyclin T1-Tat-TAR RNA complex
por: Anand, Kanchan, et al.
Publicado: (2009)

HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies
por: Asamitsu, Kaori, et al.
Publicado: (2018)

The two sides of Tat
por: Barboric, Matjaz, et al.
Publicado: (2016)

MD simulation of the Tat/Cyclin T1/CDK9 complex revealing the hidden catalytic cavity within the CDK9 molecule upon Tat binding
por: Asamitsu, Kaori, et al.
Publicado: (2017)

Molecular Dynamics Simulation and Experimental Verification of the Interaction between Cyclin T1 and HIV-1 Tat Proteins
por: Asamitsu, Kaori, et al.
Publicado: (2015)

HEXIM1-Tat chimera inhibits HIV-1 replication
por: Leoz, Marie, et al.
Publicado: (2018)

Blockade of Inflammation and Airway Hyperresponsiveness in Immune-sensitized Mice by Dominant-Negative Phosphoinositide 3-Kinase–TAT
por: Myou, Shigeharu, et al.
Publicado: (2003)

Nucleolar protein NOP2/NSUN1 suppresses HIV-1 transcription and promotes viral latency by competing with Tat for TAR binding and methylation
por: Kong, Weili, et al.
Publicado: (2020)

Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein
por: Jin, Hongping, et al.
Publicado: (2016)

Potent Inhibition of HIV-1 Replication by a Tat Mutant
por: Meredith, Luke W., et al.
Publicado: (2009)

Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription
por: Barboric, Matjaz, et al.
Publicado: (2007)

Curcumin inhibits HIV-1 by promoting Tat protein degradation
por: Ali, Amjad, et al.
Publicado: (2016)

A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat
por: Verstraete, Nina, et al.
Publicado: (2014)

Expression of human mutant cyclin dependent kinase 4, Cyclin D and telomerase extends the life span but does not immortalize fibroblasts derived from loggerhead sea turtle (Caretta caretta)
por: Fukuda, Tomokazu, et al.
Publicado: (2018)

Induced Degradation of Tat by Nucleocapsid (NC) via the Proteasome Pathway and Its Effect on HIV Transcription
por: Hong, Hye-Won, et al.
Publicado: (2013)

A Dominant-Negative FGF1 Mutant (the R50E Mutant) Suppresses Tumorigenesis and Angiogenesis
por: Mori, Seiji, et al.
Publicado: (2013)

TatB Functions as an Oligomeric Binding Site for Folded Tat Precursor Proteins
por: Maurer, Carlo, et al.
Publicado: (2010)

Strong In Vivo Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant
por: Jin, Hongping, et al.
Publicado: (2019)

Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses
por: Lara-Gonzalez, Pablo, et al.
Publicado: (2023)

p53 tetramerization: at the center of the dominant-negative effect of mutant p53
por: Gencel-Augusto, Jovanka, et al.
Publicado: (2020)

TatBC-Independent TatA/Tat Substrate Interactions Contribute to Transport Efficiency
por: Taubert, Johannes, et al.
Publicado: (2015)

Correction: A Dominant-Negative FGF1 Mutant (the R50E Mutant) Suppresses Tumorigenesis and Angiogenesis
Publicado: (2014)

Molecular dissection of TatC defines critical regions essential for protein transport and a TatB–TatC contact site
por: Kneuper, Holger, et al.
Publicado: (2012)

Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb
por: Huang, Fang, et al.
Publicado: (2021)

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity
por: McCann, Alex J, et al.
Publicado: (2021)

Unanticipated functional diversity among the TatA-type components of the Tat protein translocase
por: Eimer, Ekaterina, et al.
Publicado: (2018)

Functional characterization of the human Cdk10/Cyclin Q complex
por: Düster, Robert, et al.
Publicado: (2022)

Immune regulator ABIN1 suppresses HIV-1 transcription by negatively regulating the ubiquitination of Tat
por: Chen, Shiyou, et al.
Publicado: (2017)

Dynamic interactions of the HIV-1 Tat with nucleic acids are critical for Tat activity in reverse transcription
por: Boudier, Christian, et al.
Publicado: (2014)

P-TEFb is degraded by Siah1/2 in quiescent cells
por: Huang, Fang, et al.
Publicado: (2022)

Genetic Evidence for a Tight Cooperation of TatB and TatC during Productive Recognition of Twin-Arginine (Tat) Signal Peptides in Escherichia coli
por: Lausberg, Frank, et al.
Publicado: (2012)

How to achieve Tat transport with alien TatA
por: Hauer, René Steffen, et al.
Publicado: (2017)

AON-based degradation of c.151C>T mutant COCH transcripts associated with dominantly inherited hearing impairment DFNA9
por: de Vrieze, Erik, et al.
Publicado: (2021)

Dominant-negative mutant phenotypes and the regulation of translation elongation factor 2 levels in yeast
por: Ortiz, Pedro A., et al.
Publicado: (2005)

Transmembrane insertion of twin-arginine signal peptides is driven by TatC and regulated by TatB
por: Fröbel, Julia, et al.
Publicado: (2012)

Substrate-triggered position switching of TatA and TatB during Tat transport in Escherichia coli
por: Habersetzer, Johann, et al.
Publicado: (2017)

Comprehensive phenotypic analysis of knockout mice deficient in cyclin G1 and cyclin G2
por: Ohno, Shouichi, et al.
Publicado: (2016)

Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses
por: Bose, Deepanwita, et al.
Publicado: (2015)

Identification of a novel CDK9 inhibitor targeting the intramolecular hidden cavity of CDK9 induced by Tat binding
por: Asamitsu, Kaori, et al.
Publicado: (2022)

Tat gets the "green" light on transcription initiation
por: Brady, John, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_grb2jtfoj3rrh0sd8rai2qg8pa