Probe-specific mixed-model approach to detect copy number differences using multiplex ligation-dependent probe amplification (MLPA)

BACKGROUND: MLPA method is a potentially useful semi-quantitative method to detect copy number alterations in targeted regions. In this paper, we propose a method for the normalization procedure based on a non-linear mixed-model, as well as a new approach for determining the statistical significance...

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Detalles Bibliográficos
Autores principales: González, Juan R, Carrasco, Josep L, Armengol, Lluís, Villatoro, Sergi, Jover, Lluís, Yasui, Yutaka, Estivill, Xavier
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492880/
https://www.ncbi.nlm.nih.gov/pubmed/18522760
http://dx.doi.org/10.1186/1471-2105-9-261

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