The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts: (RNA tumor viruses/reassociation kinetics/duck cells)

A relatively simple but stringent technique was developed to detect the integration of virus-specific DNA into the genomes of higher organisms. In both permissive (duck) and nonpermissive (mammalian) cells which normally contain no nucleotide sequences specific for Rous sarcoma virus, transformation...

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Detalles Bibliográficos
Autores principales: Varmus, Harold E., Vogt, Peter K., Bishop, J. Michael
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Symposium: Molecular Genetics in Sarcoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493013/
https://www.ncbi.nlm.nih.gov/pubmed/18597148
http://dx.doi.org/10.1007/s11999-008-0355-8
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author Varmus, Harold E.
Vogt, Peter K.
Bishop, J. Michael
author_facet Varmus, Harold E.
Vogt, Peter K.
Bishop, J. Michael
author_sort Varmus, Harold E.
collection PubMed
description A relatively simple but stringent technique was developed to detect the integration of virus-specific DNA into the genomes of higher organisms. In both permissive (duck) and nonpermissive (mammalian) cells which normally contain no nucleotide sequences specific for Rous sarcoma virus, transformation by the virus results in the appearance of DNA specific for Rous sarcoma virus covalently integrated into strands of host-cell DNA containing reiterated sequences. Early after infection of mouse or duck cells by Rous sarcoma virus, unintegrated DNA specific for the virus can be demonstrated.
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spelling pubmed-24930132009-01-15 The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts: (RNA tumor viruses/reassociation kinetics/duck cells) Varmus, Harold E. Vogt, Peter K. Bishop, J. Michael Clin Orthop Relat Res Symposium: Molecular Genetics in Sarcoma A relatively simple but stringent technique was developed to detect the integration of virus-specific DNA into the genomes of higher organisms. In both permissive (duck) and nonpermissive (mammalian) cells which normally contain no nucleotide sequences specific for Rous sarcoma virus, transformation by the virus results in the appearance of DNA specific for Rous sarcoma virus covalently integrated into strands of host-cell DNA containing reiterated sequences. Early after infection of mouse or duck cells by Rous sarcoma virus, unintegrated DNA specific for the virus can be demonstrated. Springer-Verlag 2008-07-03 2008-09 /pmc/articles/PMC2493013/ /pubmed/18597148 http://dx.doi.org/10.1007/s11999-008-0355-8 Text en © The Association of Bone and Joint Surgeons 2008
spellingShingle Symposium: Molecular Genetics in Sarcoma
Varmus, Harold E.
Vogt, Peter K.
Bishop, J. Michael
The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts: (RNA tumor viruses/reassociation kinetics/duck cells)
title The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts: (RNA tumor viruses/reassociation kinetics/duck cells)
title_full The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts: (RNA tumor viruses/reassociation kinetics/duck cells)
title_fullStr The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts: (RNA tumor viruses/reassociation kinetics/duck cells)
title_full_unstemmed The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts: (RNA tumor viruses/reassociation kinetics/duck cells)
title_short The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts: (RNA tumor viruses/reassociation kinetics/duck cells)
title_sort classic: integration of deoxyribonucleic acid specific for rous sarcoma virus after infection of permissive and nonpermissive hosts: (rna tumor viruses/reassociation kinetics/duck cells)
topic Symposium: Molecular Genetics in Sarcoma
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493013/
https://www.ncbi.nlm.nih.gov/pubmed/18597148
http://dx.doi.org/10.1007/s11999-008-0355-8
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