Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity, we quantified the parallels between the genome-wi...

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Detalles Bibliográficos
Autores principales: Schumacher, Björn, van der Pluijm, Ingrid, Moorhouse, Michael J., Kosteas, Theodore, Robinson, Andria Rasile, Suh, Yousin, Breit, Timo M., van Steeg, Harry, Niedernhofer, Laura J., van IJcken, Wilfred, Bartke, Andrzej, Spindler, Stephen R., Hoeijmakers, Jan H. J., van der Horst, Gijsbertus T. J., Garinis, George A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493043/
https://www.ncbi.nlm.nih.gov/pubmed/18704162
http://dx.doi.org/10.1371/journal.pgen.1000161

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