Cargando…
Protein kinase B/Akt activity is involved in renal TGF-β1-driven epithelial-mesenchymal transition in vitro and in vivo
The molecular pathogenesis of diabetic nephropathy (DN), the leading cause of end-stage renal disease worldwide, is complex and not fully understood. Transforming growth factor-β (TGF-β1) plays a critical role in many fibrotic disorders, including DN. In this study, we report protein kinase B (PKB/A...
Autores principales: | Kattla, Jayesh J., Carew, Rosemarie M., Heljić, Mediha, Godson, Catherine, Brazil, Derek P. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Physiological Society
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494512/ https://www.ncbi.nlm.nih.gov/pubmed/18495798 http://dx.doi.org/10.1152/ajprenal.00548.2007 |
Ejemplares similares
-
PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition
por: Sun, Yating, et al.
Publicado: (2022) -
Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease
por: Roxburgh, Sarah A., et al.
Publicado: (2009) -
The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition
por: Gui, Ting, et al.
Publicado: (2012) -
Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition
por: Moustakas, Aristidis, et al.
Publicado: (2016) -
Combinatorial interventions inhibit TGFβ-driven epithelial-to-mesenchymal transition and support hybrid cellular phenotypes
por: Steinway, Steven Nathaniel, et al.
Publicado: (2015)