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Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function

OBJECTIVE—To evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (TG) content and myocardial function in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS—Myocardial and hepatic TG content and left ventricular (LV) function were measured by ma...

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Autores principales: Hammer, Sebastiaan, Jonker, Jacqueline T., Lamb, Hildo J., van der Meer, Rutger W., Zondag, Wendy, Sepers, Jan M., de Roos, Albert, Smit, Johannes W.A., Romijn, Johannes A.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494624/
https://www.ncbi.nlm.nih.gov/pubmed/18458137
http://dx.doi.org/10.2337/dc08-0513
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author Hammer, Sebastiaan
Jonker, Jacqueline T.
Lamb, Hildo J.
van der Meer, Rutger W.
Zondag, Wendy
Sepers, Jan M.
de Roos, Albert
Smit, Johannes W.A.
Romijn, Johannes A.
author_facet Hammer, Sebastiaan
Jonker, Jacqueline T.
Lamb, Hildo J.
van der Meer, Rutger W.
Zondag, Wendy
Sepers, Jan M.
de Roos, Albert
Smit, Johannes W.A.
Romijn, Johannes A.
author_sort Hammer, Sebastiaan
collection PubMed
description OBJECTIVE—To evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (TG) content and myocardial function in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS—Myocardial and hepatic TG content and left ventricular (LV) function were measured by magnetic resonance (MR) spectroscopy and MR imaging during optimal glucoregulation and after 24 h of partial insulin deprivation (n = 10). RESULTS—Mean insulin infusion rate was 45 ± 5 units at baseline, whereas it was 27 ± 5 units during hyperglycemia (per 24 h, P < 0.001). Plasma glucose levels increased from 8.4 ± 0.6 to 15.9 ± 0.8 mmol/l (P < 0.001), and plasma levels of nonesterified fatty acids from 0.31 ± 0.05 to 0.46 ± 0.07 mmol/l (P = 0.015). Hyperglycemia had no effects on myocardial or hepatic TG content and LV function. CONCLUSIONS—Short-term hyperglycemic dysregulation does not modulate myocardial or hepatic TG content or myocardial function, despite considerable metabolic adaptations.
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spelling pubmed-24946242009-08-01 Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function Hammer, Sebastiaan Jonker, Jacqueline T. Lamb, Hildo J. van der Meer, Rutger W. Zondag, Wendy Sepers, Jan M. de Roos, Albert Smit, Johannes W.A. Romijn, Johannes A. Diabetes Care Pathophysiology/Complications OBJECTIVE—To evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (TG) content and myocardial function in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS—Myocardial and hepatic TG content and left ventricular (LV) function were measured by magnetic resonance (MR) spectroscopy and MR imaging during optimal glucoregulation and after 24 h of partial insulin deprivation (n = 10). RESULTS—Mean insulin infusion rate was 45 ± 5 units at baseline, whereas it was 27 ± 5 units during hyperglycemia (per 24 h, P < 0.001). Plasma glucose levels increased from 8.4 ± 0.6 to 15.9 ± 0.8 mmol/l (P < 0.001), and plasma levels of nonesterified fatty acids from 0.31 ± 0.05 to 0.46 ± 0.07 mmol/l (P = 0.015). Hyperglycemia had no effects on myocardial or hepatic TG content and LV function. CONCLUSIONS—Short-term hyperglycemic dysregulation does not modulate myocardial or hepatic TG content or myocardial function, despite considerable metabolic adaptations. American Diabetes Association 2008-08 /pmc/articles/PMC2494624/ /pubmed/18458137 http://dx.doi.org/10.2337/dc08-0513 Text en Copyright © 2008, American Diabetes Association Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Pathophysiology/Complications
Hammer, Sebastiaan
Jonker, Jacqueline T.
Lamb, Hildo J.
van der Meer, Rutger W.
Zondag, Wendy
Sepers, Jan M.
de Roos, Albert
Smit, Johannes W.A.
Romijn, Johannes A.
Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function
title Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function
title_full Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function
title_fullStr Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function
title_full_unstemmed Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function
title_short Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function
title_sort short-term hyperglycemic dysregulation in patients with type 1 diabetes does not change myocardial triglyceride content or myocardial function
topic Pathophysiology/Complications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494624/
https://www.ncbi.nlm.nih.gov/pubmed/18458137
http://dx.doi.org/10.2337/dc08-0513
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