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Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring

OBJECTIVE—Epidemiological and experimental studies have led to the hypothesis of fetal origin of adult diseases, suggesting that some adult diseases might be determined before birth by altered fetal development. We have previously demonstrated in the rat that in utero exposure to maternal diabetes i...

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Autores principales: Nehiri, Touria, Van Huyen, Jean-Paul Duong, Viltard, Mélanie, Fassot, Céline, Heudes, Didier, Freund, Nicole, Deschênes, Georges, Houillier, Pascal, Bruneval, Patrick, Lelièvre-Pégorier, Martine
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494671/
https://www.ncbi.nlm.nih.gov/pubmed/18443204
http://dx.doi.org/10.2337/db07-0780
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author Nehiri, Touria
Van Huyen, Jean-Paul Duong
Viltard, Mélanie
Fassot, Céline
Heudes, Didier
Freund, Nicole
Deschênes, Georges
Houillier, Pascal
Bruneval, Patrick
Lelièvre-Pégorier, Martine
author_facet Nehiri, Touria
Van Huyen, Jean-Paul Duong
Viltard, Mélanie
Fassot, Céline
Heudes, Didier
Freund, Nicole
Deschênes, Georges
Houillier, Pascal
Bruneval, Patrick
Lelièvre-Pégorier, Martine
author_sort Nehiri, Touria
collection PubMed
description OBJECTIVE—Epidemiological and experimental studies have led to the hypothesis of fetal origin of adult diseases, suggesting that some adult diseases might be determined before birth by altered fetal development. We have previously demonstrated in the rat that in utero exposure to maternal diabetes impairs renal development leading to a reduction in nephron number. Little is known on the long-term consequences of in utero exposure to maternal diabetes. The aim of the study was to assess, in the rat, long-term effects of in utero exposure to maternal diabetes on blood pressure and renal function in adulthood. RESEARCH DESIGN AND METHODS—Diabetes was induced in Sprague-Dawley pregnant rats by streptozotocin on day 0 of gestation. Systolic blood pressure, plasma renin activity, and renal function were measured in the offspring from 1 to 18 months of age. High-salt diet experiments were performed at the prehypertensive stage, and the abundance of tubular sodium transporters was evaluated by Western blot analysis. Kidney tissues were processed for histopathology and glomerular computer-assisted histomorphometry. RESULTS AND CONCLUSIONS—We demonstrated that in utero exposure to maternal diabetes induces a salt-sensitive hypertension in the offspring associated with a decrease in renal function in adulthood. High-salt diet experiments show an alteration of renal sodium handling that may be explained by a fetal reprogramming of tubular functions in association or as a result of the inborn nephron deficit induced by in utero exposure to maternal diabetes.
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spelling pubmed-24946712009-08-01 Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring Nehiri, Touria Van Huyen, Jean-Paul Duong Viltard, Mélanie Fassot, Céline Heudes, Didier Freund, Nicole Deschênes, Georges Houillier, Pascal Bruneval, Patrick Lelièvre-Pégorier, Martine Diabetes Complications OBJECTIVE—Epidemiological and experimental studies have led to the hypothesis of fetal origin of adult diseases, suggesting that some adult diseases might be determined before birth by altered fetal development. We have previously demonstrated in the rat that in utero exposure to maternal diabetes impairs renal development leading to a reduction in nephron number. Little is known on the long-term consequences of in utero exposure to maternal diabetes. The aim of the study was to assess, in the rat, long-term effects of in utero exposure to maternal diabetes on blood pressure and renal function in adulthood. RESEARCH DESIGN AND METHODS—Diabetes was induced in Sprague-Dawley pregnant rats by streptozotocin on day 0 of gestation. Systolic blood pressure, plasma renin activity, and renal function were measured in the offspring from 1 to 18 months of age. High-salt diet experiments were performed at the prehypertensive stage, and the abundance of tubular sodium transporters was evaluated by Western blot analysis. Kidney tissues were processed for histopathology and glomerular computer-assisted histomorphometry. RESULTS AND CONCLUSIONS—We demonstrated that in utero exposure to maternal diabetes induces a salt-sensitive hypertension in the offspring associated with a decrease in renal function in adulthood. High-salt diet experiments show an alteration of renal sodium handling that may be explained by a fetal reprogramming of tubular functions in association or as a result of the inborn nephron deficit induced by in utero exposure to maternal diabetes. American Diabetes Association 2008-08 /pmc/articles/PMC2494671/ /pubmed/18443204 http://dx.doi.org/10.2337/db07-0780 Text en Copyright © 2008, American Diabetes Association Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Complications
Nehiri, Touria
Van Huyen, Jean-Paul Duong
Viltard, Mélanie
Fassot, Céline
Heudes, Didier
Freund, Nicole
Deschênes, Georges
Houillier, Pascal
Bruneval, Patrick
Lelièvre-Pégorier, Martine
Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring
title Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring
title_full Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring
title_fullStr Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring
title_full_unstemmed Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring
title_short Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring
title_sort exposure to maternal diabetes induces salt-sensitive hypertension and impairs renal function in adult rat offspring
topic Complications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494671/
https://www.ncbi.nlm.nih.gov/pubmed/18443204
http://dx.doi.org/10.2337/db07-0780
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