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siRNA-Mediated Reduction of Inhibitor of Nuclear Factor-κB Kinase Prevents Tumor Necrosis Factor-α–Induced Insulin Resistance in Human Skeletal Muscle

OBJECTIVE—Proinflammatory cytokines contribute to systemic low-grade inflammation and insulin resistance. Tumor necrosis factor (TNF)-α impedes insulin signaling in insulin target tissues. We determined the role of inhibitor of nuclear factor-κB kinase (IKK)β in TNF-α–induced impairments in insulin...

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Detalles Bibliográficos
Autores principales:	Austin, Reginald L., Rune, Anna, Bouzakri, Karim, Zierath, Juleen R., Krook, Anna
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494681/ https://www.ncbi.nlm.nih.gov/pubmed/18443205 http://dx.doi.org/10.2337/db07-0763

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