Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice

OBJECTIVE— Acute activation of G protein–coupled receptor 40 (GPR40) by free fatty acids (FFAs) or synthetic GPR40 agonists enhances insulin secretion. However, it is still a matter of debate whether activation of GPR40 would be beneficial for the treatment of type 2 diabetes, since chronic exposure...

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Detalles Bibliográficos
Autores principales: Tan, Carina P., Feng, Yue, Zhou, Yun-Ping, Eiermann, George J., Petrov, Aleksandr, Zhou, Changyou, Lin, Songnian, Salituro, Gino, Meinke, Peter, Mosley, Ralph, Akiyama, Taro E., Einstein, Monica, Kumar, Sanjeev, Berger, Joel P., Mills, Sander G., Thornberry, Nancy A., Yang, Lihu, Howard, Andrew D.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494688/
https://www.ncbi.nlm.nih.gov/pubmed/18477808
http://dx.doi.org/10.2337/db08-0130

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