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The Effect of a ΔK280 Mutation on the Unfolded State of a Microtubule-Binding Repeat in Tau
Tau is a natively unfolded protein that forms intracellular aggregates in the brains of patients with Alzheimer's disease. To decipher the mechanism underlying the formation of tau aggregates, we developed a novel approach for constructing models of natively unfolded proteins. The method, energ...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494868/ https://www.ncbi.nlm.nih.gov/pubmed/18725924 http://dx.doi.org/10.1371/journal.pcbi.1000155 |