Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

Vaccinia virus (VACV), the prototype poxvirus, encodes numerous proteins that modulate the host response to infection. Two such proteins, B14 and A52, act inside infected cells to inhibit activation of NF-κB, thereby blocking the production of pro-inflammatory cytokines. We have solved the crystal s...

Descripción completa

Detalles Bibliográficos
Autores principales: Graham, Stephen C., Bahar, Mohammad W., Cooray, Samantha, Chen, Ron A.-J., Whalen, Daniel M., Abrescia, Nicola G. A., Alderton, David, Owens, Raymond J., Stuart, David I., Smith, Geoffrey L., Grimes, Jonathan M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494871/
https://www.ncbi.nlm.nih.gov/pubmed/18704168
http://dx.doi.org/10.1371/journal.ppat.1000128

Ejemplares similares

Ejemplares similares