Activation of mitotic kinesin by microtubule bundling

Kinesin-5 family members cross-link and slide parallel microtubules of opposite polarity, an activity that is essential for the formation of a bipolar spindle during mitosis. In this issue, Kapitein et al. (Kapitein, L.C., B.H. Kwok, J.S. Weinger, C.F. Schmidt, T.M. Kapoor, and E.J.G. Peterman. 2008...

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Detalles Bibliográficos
Autor principal: Tomishige, Michio
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2500127/
https://www.ncbi.nlm.nih.gov/pubmed/18678712
http://dx.doi.org/10.1083/jcb.200807093
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author Tomishige, Michio
author_facet Tomishige, Michio
author_sort Tomishige, Michio
collection PubMed
description Kinesin-5 family members cross-link and slide parallel microtubules of opposite polarity, an activity that is essential for the formation of a bipolar spindle during mitosis. In this issue, Kapitein et al. (Kapitein, L.C., B.H. Kwok, J.S. Weinger, C.F. Schmidt, T.M. Kapoor, and E.J.G. Peterman. 2008. J. Cell Biol. 182:421–428) demonstrate that microtubule cross-linking triggers the conversion of kinesin-5 motility from a diffusive mode to a directional mode, initiating antiparallel microtubule sliding.
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spelling pubmed-25001272009-02-11 Activation of mitotic kinesin by microtubule bundling Tomishige, Michio J Cell Biol Reviews Kinesin-5 family members cross-link and slide parallel microtubules of opposite polarity, an activity that is essential for the formation of a bipolar spindle during mitosis. In this issue, Kapitein et al. (Kapitein, L.C., B.H. Kwok, J.S. Weinger, C.F. Schmidt, T.M. Kapoor, and E.J.G. Peterman. 2008. J. Cell Biol. 182:421–428) demonstrate that microtubule cross-linking triggers the conversion of kinesin-5 motility from a diffusive mode to a directional mode, initiating antiparallel microtubule sliding. The Rockefeller University Press 2008-08-11 /pmc/articles/PMC2500127/ /pubmed/18678712 http://dx.doi.org/10.1083/jcb.200807093 Text en © 2008 Tomishige This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Tomishige, Michio
Activation of mitotic kinesin by microtubule bundling
title Activation of mitotic kinesin by microtubule bundling
title_full Activation of mitotic kinesin by microtubule bundling
title_fullStr Activation of mitotic kinesin by microtubule bundling
title_full_unstemmed Activation of mitotic kinesin by microtubule bundling
title_short Activation of mitotic kinesin by microtubule bundling
title_sort activation of mitotic kinesin by microtubule bundling
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2500127/
https://www.ncbi.nlm.nih.gov/pubmed/18678712
http://dx.doi.org/10.1083/jcb.200807093
work_keys_str_mv AT tomishigemichio activationofmitotickinesinbymicrotubulebundling

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