Cargando…

Novel Meta-Analysis-Derived Type 2 Diabetes Risk Loci Do Not Determine Prediabetic Phenotypes

BACKGROUND: Genome-wide association (GWA) studies identified a series of novel type 2 diabetes risk loci. Most of them were subsequently demonstrated to affect insulin secretion of pancreatic β-cells. Very recently, a meta-analysis of GWA data revealed nine additional risk loci with still undefined...

Descripción completa

Detalles Bibliográficos
Autores principales:	Staiger, Harald, Machicao, Fausto, Kantartzis, Konstantinos, Schäfer, Silke A., Kirchhoff, Kerstin, Guthoff, Martina, Silbernagel, Günther, Stefan, Norbert, Fritsche, Andreas, Häring, Hans-Ulrich
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2500187/ https://www.ncbi.nlm.nih.gov/pubmed/18714373 http://dx.doi.org/10.1371/journal.pone.0003019

Ejemplares similares

Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function
por: Staiger, Harald, et al.
Publicado: (2008)

Polymorphisms within Novel Risk Loci for Type 2 Diabetes Determine β-Cell Function
por: Staiger, Harald, et al.
Publicado: (2007)

Association of Type 2 Diabetes Candidate Polymorphisms in KCNQ1 With Incretin and Insulin Secretion
por: Müssig, Karsten, et al.
Publicado: (2009)

Evaluation of Fasting State-/Oral Glucose Tolerance Test-Derived Measures of Insulin Release for the Detection of Genetically Impaired β-Cell Function
por: Herzberg-Schäfer, Silke A., et al.
Publicado: (2010)

Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
por: Peter, Andreas, et al.
Publicado: (2010)

Glycemia Determines the Effect of Type 2 Diabetes Risk Genes on Insulin Secretion
por: Heni, Martin, et al.
Publicado: (2010)

Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin
por: Wagner, Robert, et al.
Publicado: (2011)

Association of Common Genetic Variants in the MAP4K4 Locus with Prediabetic Traits in Humans
por: Sartorius, Tina, et al.
Publicado: (2012)

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced β-cell function in non-diabetic subjects
por: Weyrich, Peter, et al.
Publicado: (2009)

Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion
por: Heni, Martin, et al.
Publicado: (2010)

Fetuin-A Induces Cytokine Expression and Suppresses Adiponectin Production
por: Hennige, Anita M., et al.
Publicado: (2008)

The D299G/T399I Toll-Like Receptor 4 Variant Associates with Body and Liver Fat: Results from the TULIP and METSIM Studies
por: Weyrich, Peter, et al.
Publicado: (2010)

Dietary Fiber Intake Modulates the Association Between Variants in TCF7L2 and Weight Loss During a Lifestyle Intervention
por: Heni, Martin, et al.
Publicado: (2012)

No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes
por: Müssig, Karsten, et al.
Publicado: (2010)

DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity
por: Böhm, Anja, et al.
Publicado: (2017)

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene
por: Kantartzis, Konstantinos, et al.
Publicado: (2009)

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans
por: Staiger, Harald, et al.
Publicado: (2009)

Allele Summation of Diabetes Risk Genes Predicts Impaired Glucose Tolerance in Female and Obese Individuals
por: Linder, Katarzyna, et al.
Publicado: (2012)

Cholesterol Synthesis Is Associated with Hepatic Lipid Content and Dependent on Fructose/Glucose Intake in Healthy Humans
por: Silbernagel, Guenther, et al.
Publicado: (2012)

Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans
por: Ordelheide, Anna-Maria, et al.
Publicado: (2016)

Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans
por: Lutz, Stefan Z., et al.
Publicado: (2018)

Common variation in the sodium/glucose cotransporter 2 gene SLC5A2 does neither affect fasting nor glucose-suppressed plasma glucagon concentrations
por: Ordelheide, Anna-Maria, et al.
Publicado: (2017)

Polymorphism rs11085226 in the Gene Encoding Polypyrimidine Tract-Binding Protein 1 Negatively Affects Glucose-Stimulated Insulin Secretion
por: Heni, Martin, et al.
Publicado: (2012)

Gene x Gene Interactions Highlight the Role of Incretin Resistance for Insulin Secretion
por: Jaghutriz, Benjamin Assad, et al.
Publicado: (2019)

Common Genetic Variation in the Human CTF1 Locus, Encoding Cardiotrophin-1, Determines Insulin Sensitivity
por: Lutz, Stefan Z., et al.
Publicado: (2014)

Circulating Palmitoleate Strongly and Independently Predicts Insulin Sensitivity in Humans
por: Stefan, Norbert, et al.
Publicado: (2010)

Diabetes Mellitus and Prediabetes on Kidney Transplant Waiting List- Prevalence, Metabolic Phenotyping and Risk Stratification Approach
por: Guthoff, Martina, et al.
Publicado: (2015)

Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes
por: Heni, Martin, et al.
Publicado: (2011)

Common Genetic Variation in the SERPINF1 Locus Determines Overall Adiposity, Obesity-Related Insulin Resistance, and Circulating Leptin Levels
por: Böhm, Anja, et al.
Publicado: (2012)

Gene Variants of TCF7L2 Influence Weight Loss and Body Composition During Lifestyle Intervention in a Population at Risk for Type 2 Diabetes
por: Haupt, Axel, et al.
Publicado: (2010)

Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers
por: Kächele, Martin, et al.
Publicado: (2015)

Novel phenotypes of prediabetes?
por: Häring, Hans-Ulrich
Publicado: (2016)

Glucose-Raising Polymorphisms in the Human Clock Gene Cryptochrome 2 (CRY2) Affect Hepatic Lipid Content
por: Machicao, Fausto, et al.
Publicado: (2016)

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity
por: Staiger, Harald, et al.
Publicado: (2013)

Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo
por: Peter, Andreas, et al.
Publicado: (2009)

Cerebrocortical Beta Activity in Overweight Humans Responds to Insulin Detemir
por: Tschritter, Otto, et al.
Publicado: (2007)

Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies
por: Wagner, Róbert, et al.
Publicado: (2017)

Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1()
por: Wagner, Robert, et al.
Publicado: (2014)

FTO Genotype Interacts with Improvement in Aerobic Fitness on Body Weight Loss During Lifestyle Intervention
por: Sailer, Corinna, et al.
Publicado: (2016)

Lower Plasma Creatinine and Urine Albumin in Individuals at Increased Risk of Type 2 Diabetes with Factor V Leiden Mutation
por: Peter, Andreas, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_n5skgi0i8e2qmekp285jbv311t